Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Jon Cryer, Chris Kentis, Renee Olstead
- Episode 2: Dennis Leary, Sam Easterson
- Episode 3: Paul Hamm, Josh Hartnett, Nick Cave
- Episode 4: Natalie Coughlin, Carla Gugino, Gavin DeGraw
- Episode 5: Maureen Dowd, Tom Ryan
- Episode 6: Carly Patterson, Jeff Foxworthy, LL Cool J
- Episode 7: Farrah Fawcett, The Clarks
- Episode 8: John McCain, Tom Russell
- Episode 9: Tim Russert, Snow Patrol
- Episode 10: Jane Pauley, Greg Giraldo
- Episode 11: National Hollerin' Champions, Neve Campbell, Keane
- Episode 12: Regis Philbin, Hoobastank
- Episode 13: Martin Short, Alan Jackson
- Episode 14: Ray Romano, Avril Lavigne
- Episode 15: Drew Barrymore, Aron Ralston
- Episode 16: John Kerry, Green Day
- Episode 17: Dr. Phil, Gary Sinise
- Episode 18: Kelly Ripa, Annie Duke, Elvis Costello
- Episode 19: Stupid Human Tricks, Rob Lowe, Mos Def
- Episode 20: Julianne Moore, Tom Dreesen
- Episode 21: Queen Latifah, Jack Hanna
- Episode 22: John Goodman, Tom Waits
- Episode 23: Joaquin Phoenix, Austin Stevens, Switchfoot
- Episode 24: John Travolta, Tim Frisby, Pearl Jam
- Episode 25: Richard Gere, Jason Randal
- Episode 26: Howard Dean, Franz Ferdinand
- Episode 27: Annette Bening, Bill O'Reilly
- Episode 28: Jamie Foxx, Davy Rothbart
- Episode 29: Donald Trump, Brian Binnie, Minnie Driver
- Episode 30: Brooke Shields, Barry Sonnenfeld
- Episode 31: Melina Kanakaredes, Paul Teutul Sr. and Paul Teutul Jr., Ben Harper and the Blind Boys of Alabama
- Episode 32: Laura Linney, Richard Lewis, The Wallflowers and Jordan Zevon
- Episode 33: Jennifer Lopez, Sue Johanson
- Episode 34: Billy Crystal, Ralph Nader
- Episode 35: Tony Danza, Emma Roberts, Brian Regan
- Episode 36: Jimmy Carter, Brandi Chastain, John Mellencamp
- Episode 37: Jude Law, Ricky Gervais
- Episode 38: Sarah Michelle Gellar, Tony Kanaan, Sparta
- Episode 39: Dustin Hoffman, Joss Stone
- Episode 40: Amy Sedaris, Tommy Lee
- Episode 41: Johnny Damon, Anne Heche, The Donnas
- Episode 42: Tom Brokaw, Mischa Barton
- Episode 43: Rosie Perez, Steven Wright
- Episode 44: Al Franken, Kristin Bell
- Episode 45: Tom Hanks, Nelly
- Episode 46: Salma Hayek, Sebastian Bourdais, Jimmy Eat World
- Episode 47: Pierce Brosnan, Nigella Lawson, Renee Fleming
- Episode 48: Matthew Broderick, Rosario Dawson, Los Lonely Boys
- Episode 49: Paul Reubens, Evangeline Lilly, Project Bandaloop
- Episode 50: Jerry Seinfeld, Jamie Oliver
- Episode 51: Nicolas Cage, Jason Alexander, Morrissey
- Episode 52: Renee Zellweger, Chris Raxworthy
- Episode 53: Howard Stern, Alanis Morissette
- Episode 54: Tom Brady, Damien Fahey
- Episode 55: Stupid Pet Tricks, Colin Farrell, The Walkmen
- Episode 56: Kevin Spacey, Ben Roethlisberger, Streb
- Episode 57: Whoopi Goldberg, Jason Bateman, Marilyn Manson
- Episode 58: Natalie Portman, John Mayer
- Episode 59: Barack Obama, Jessica Biel
- Episode 60: Matt Damon, Lance Armstrong
- Episode 61: Alec Baldwin, Ken Jennings
- Episode 62: Stupid Human Tricks, Noah Wylie, Sum 41
- Episode 63: Sharon Reed, Tyra Banks, Lyle Lovett
- Episode 64: Bonnie Hunt, Alex Zanardi
- Episode 65: Jim Carrey, Ashanti
- Episode 66: Cate Blanchett, Craig Ferguson, The Pixies
- Episode 67: Adam Sandler, Sharon Ice
- Episode 68: Kate Beckinsale, Ciara and Missy Elliot
- Episode 69: Jeff Goldblum, Terrell Owens
- Episode 70: Bill Murray, Kaki King
- Episode 71: Dennis Quaid, Rusty Wallace, Kaki King
- Episode 72: Kristin Johnson, Tom Dreesen
- Episode 73: Regis Philbin, Jay Thomas, Darlene Love
- Episode 74: Hilary Swank, Andy Dick, Green Day
- Episode 75: Ethan Hawke, Maria Menounos, Alicia Keys
- Episode 76: Kiefer Sutherland, Marv Albert, The Black Keys
- Episode 77: Michael Keaton, Jamie Lynn Spears
- Episode 78: Kevin Bacon, Caroline Rhea, Wilco
- Episode 79: Samuel L. Jackson, Amy Poehler, B.B. King
- Episode 80: Randy Johnson, Aisha Tyler, Razorlight
- Episode 81: Rudolph Giuliani, Daniel Banks
- Episode 82: Marge Helgenberger, Ryan Seacrest, My Chemical Romance
- Episode 83: Amy Sedaris, Andy Kindler
- Episode 84: Jack Hanna, Teri Polo
- Episode 85: Ice Cube, Chris Russo, Interpol
- Episode 86: Harvey Fierstein, Regina King, Steven Van Zandt, ... And You Will Know Us By the Trail of Dead
- Episode 87: Robert Downey Jr., Nicole Richie
- Episode 88: Jerry Lewis, Sophia Bush
- Episode 89: Peter Lassally, Doc Severinson
- Episode 90: Debra Messing, Peyton Manning
- Episode 91: Patricia Heaton, John Witherspoon, Gibson/Baldwin Grammy Jazz Ensembles
- Episode 92: Elton John, Eva Mendes
- Episode 93: Al Franken, Matthew Fox, Nanci Griffith
- Episode 94: Will Smith, Tom Brady
- Episode 95: Kevin James, Aishwarya Rai, Three Doors Down
- Episode 96: David Hyde Pierce, Howie Day
- Episode 97: Billy Crystal, Patrick Lawler
- Episode 98: Paris Hilton, Bill Burr
- Episode 99: Dr. Phil, Unwritten Law
- Episode 100: Kid Scientists, Keanu Reeves, Michael Buble
- Episode 101: Kelly Ripa, Taye Diggs
- Episode 102: Charlie Sheen, Tori Amos
- Episode 103: Roseanne Barr, Rachel Weisz
- Episode 104: Stupid Pet Tricks, Bonnie Hunt
- Episode 105: Barbara Walters, Rachel Bilson, Kings of Leon
- Episode 106: Michael J. Fox, Amanda Bynes
- Episode 107: John Travolta, Tony Kornheiser and Michael Wilbon
- Episode 108: Ricky Gervais, Rachel Ray
- Episode 109: The Rock, Solomon Burke
- Episode 110: Kirstie Alley, Kathleen Edwards
- Episode 111: Vin Diesel, Amos Lee
- Episode 112: Dan Rather, Poppy Montgomery
- Episode 113: Bruce Willis, Greg Giraldo
- Episode 114: Ashton Kutcher, Al Green
- Episode 115: Jimmy Fallon, Emily VanCamp, The Four Tops
- Episode 116: Amanda Peet, Dean Kamazes
- Episode 117: Sandra Bullock, Gwen Stefani
- Episode 118: Jessica Alba, Brian Greene, Queens of the Stone Age
- Episode 119: P. Diddy, Erika Christensen
- Episode 120: Queen Latifah, Seth McFarlane
- Episode 121: Britany Murphy, Bob Sarlatte, The John Butler Trio
- Episode 122: Penelope Cruz, Sarah Vowell, Kaiser Chiefs
- Episode 123: Denzel Washington, Faith Evans
- Episode 124: Lisa Marie Presley, Ahmed Ibrahim, Jake Johannsen
- Episode 125: Drew Barrymore, Charles Barkley
- Episode 126: Show #2345
- Episode 127: Show #2346
- Episode 128: Mickey Rourke, Jason Randal
- Episode 129: David Duchovny, Ray Lamontagne
- Episode 130: Anthony LaPaglia, Ana Gasteyer, Mariah Carey
- Episode 131: Kristin Chenowith, Johnny Lechner, Ludacris
- Episode 132: Farrah Fawcett, Martin Freeman
- Episode 133: Hank Azaria, Jeff MacGregor
- Episode 134: Amy Sedaris, Daniel Tammet, LCD Soundsystem
- Episode 135: Paris Hilton, Jo Frost
- Episode 136: Teri Hatcher, Harry Hill
- Episode 137: Martin Short, Elisha Cuthbert
- Episode 138: Jennifer Lopez, Snoop Dogg
- Episode 139: Orlando Bloom, Jack Hanna
- Episode 140: Luke Wilson, Kasabian
- Episode 141: Stupid Human Tricks, Christina Applegate, Brian Regan
- Episode 142: Will Ferrell, Robert Plant
- Episode 143: Helen Hunt, Tom Dreesen
- Episode 144: Priscilla Presley, Quentin Tarantino
- Episode 145: Billy Crystal, Garbage
- Episode 146: Samuel L. Jackson, Sting
- Episode 147: Ray Ramono, Dave Matthews Band
- Episode 148: Ben Stiller, Sherry Fairchild
- Episode 149: Chris Rock, Nicolette Sheridan
- Episode 150: Ellen Degeneres, Hot Hot Heat
- Episode 151: David Arquette, Gordon Ramsey
- Episode 152: Paul Newman, Danica Patrick, Adam Savage & Jamie Hyneman
- Episode 153: Adam Sandler, Reggie Miller, The Wallflowers
- Episode 154: Kelly Ripa, Alexis Bledel, Ryan Adams & The Cardinals
- Episode 155: Cedric the Entertainer, Dan Wheldon, The Black Eyed Peas
- Episode 157: Russel Crowe, Paul Anka
- Episode 158: Katie Holmes, The Shout Out Louds
- Episode 159: Al Franken, Ellen Pompeo
- Episode 160: Nicole Kidman, Foo Fighters
- Episode 161: Show #2380
- Episode 162: Show #2381
- Episode 163: Show #2382
- Episode 164: Show #2383
- Episode 165: Show #2384
- Episode 166: Show #2385
- Episode 167: Show #2386
- Episode 168: Show #2387
- Episode 169: Show #2388
- Episode 170: Show #2389
- Episode 171: Julian McMahon/Raul Midon/Piedmont Bird Callers
- Episode 172: Tom Brokaw/Dakota Fanning
- Episode 173: Jennifer Connelly/Eels
- Episode 174: Episode #12.174
- Episode 175: Show #2394
- Episode 176: Show #2395
- Episode 177: Show #2396
- Episode 178: Show #2397
- Episode 179: Show #2398
- Episode 180: John Cusack/The All-American Rejects
- Episode 181: Show #2400
- Episode 182: Kelly Preston/Jeff Altman/Aimee Mann
- Episode 183: Bill Murray/Bettye LaVette
- Episode 184: Show #2403
- Episode 185: Lance Armstrong/Michael Ian Black
- Episode 186: Show #2405
- Episode 187: Show #2406
- Episode 188: Show #2407
- Episode 189: Show #2408
- Episode 190: Show #2409
- Episode 191: Show #2410
- Episode 192: Show #2411
- Episode 193: Show #2412
- Episode 194: Show #2413
Late Show with David Letterman - Season 12 Episode 140 : Luke Wilson, Kasabian
Live via satellite, Dorothy Letterman performs the Top Ten; in honor of Cinco De Mayo, a city bus crashes into a giant pinata; Kasabian performs ""Club Foot.""
