Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Show #2414
- Episode 2: Show #2415
- Episode 3: Show #2416
- Episode 4: Show #2417
- Episode 5: Show #2418
- Episode 6: Show #2419
- Episode 7: Show #2420
- Episode 8: Show #2421
- Episode 9: Show #2422
- Episode 10: Show #2423
- Episode 11: Show #2424
- Episode 12: Show #2425
- Episode 13: Show #2426
- Episode 14: Show #2427
- Episode 15: Show #2428
- Episode 16: Show #2429
- Episode 17: Show #2430
- Episode 18: Show #2431
- Episode 19: Show #2432
- Episode 20: Show #2433
- Episode 21: Show #2434
- Episode 22: Show #2435
- Episode 23: Show #2436
- Episode 24: Show #2437
- Episode 25: Show #2438
- Episode 26: Show #2439
- Episode 27: Show #2440
- Episode 28: Show #2441
- Episode 29: Show #2442
- Episode 30: Show #2443
- Episode 31: Show #2444
- Episode 32: Show #2445
- Episode 33: Show #2446
- Episode 34: Show #2447
- Episode 35: Show #2448
- Episode 36: Show #2449
- Episode 37: Show #2450
- Episode 38: Show #2451
- Episode 39: Show #2452
- Episode 40: Show #2453
- Episode 41: Jennifer Aniston, 50 Cent
- Episode 42: Matthew Broderick, Teri Garr
- Episode 43: Kelly Ripa, Hilary Duff
- Episode 44: Steve Martin, the Teutul family from "American Chopper"
- Episode 45: Ted Koppel, Jim Gaffigan, Trey Anastasio
- Episode 46: Kid scientists, John Cusack
- Episode 47: Joaquin Phoenix, Trisha Yearwood
- Episode 48: Ellen DeGeneres, Brad Paisley
- Episode 49: Howard Stern, Pharrell Williams
- Episode 50: Sen. John McCain, Carla Gugino
- Episode 51: George Clooney, Ashlee Simpson
- Episode 52: Dennis Quaid, Donovan McNabb
- Episode 53: Stupid Pet Tricks, Claire Danes, Big Boi
- Episode 54: Megan Mullally, John Mayer Trio
- Episode 55: John Malkovich, NASCAR Nextel Cup winner, Jim Gaffigan
- Episode 56: Stupid Human Tricks, Amanda Peet
- Episode 57: Regis Philbin, Colin Hanks
- Episode 58: Charlize Theron, Maureen Dowd
- Episode 59: Oprah Winfrey, Bonnie Raitt
- Episode 60: Rodeo champion Billy Etbauer
- Episode 61: Jack Black, Reggie Bush, Sinead O'Connor
- Episode 62: Sarah Jessica Parker, John Witherspoon
- Episode 63: Stephen Colbert, Aqualung
- Episode 64: Alec Baldwin, Shakira
- Episode 65: Dr. Phil McGraw, Bill Scheft
- Episode 66: Jim Carrey, We Are Scientists
- Episode 67: Bonnie Hunt, Stephen A. Smith
- Episode 68: Nathan Lane, Tom Dreesen
- Episode 69: Jamie Foxx, Andy Kindler
- Episode 70: Rosie Perez, Jay Thomas, Darlene Love
- Episode 71: Heather Graham, Fall Out Boy
- Episode 72: Bill O'Reilly, Eric Bana
- Episode 73: Pierce Brosnan, Marv Albert
- Episode 74: Felicity Huffman, David Rakoff, Common
- Episode 75: Amy Sedaris, Dennis Regan, the Temptations
- Episode 76: Albert Brooks, Kristin Cavallari
- Episode 77: Scarlett Johannsen, Tiki Barber, Imogen Heap
- Episode 78: Queen Latifah, Bob Sarlatte
- Episode 79: Kiefer Sutherland, Alicia Keys, Andy Samberg
- Episode 80: Tom Cavanagh, Jake Johannsen
- Episode 81: Martin Lawrence, Kari Byron, Matisyahu
- Episode 82: Tatum O'Neal, Jeff MacGregor
- Episode 83: Kate Beckinsale, Bob Saget
- Episode 84: Cheryl Hines, Anna Nalick, Mike Vanderjagt
- Episode 85: Charles Grodin, Jordana Brewster
- Episode 86: Anthony Hopkins
- Episode 87: Bernie Mac, Beth Orton
- Episode 88: Mischa Barton, Jeff Altman, Wicked Wisdom
- Episode 89: Tommy Lee Jones, Anthony Hamilton
- Episode 90: P Diddy, Train
- Episode 91: Harrison Ford, Michael Bublé
- Episode 92: Beyonce Knowles, Stephen A. Smith
- Episode 93: Rachel Weisz, Beastie Boys
- Episode 94: Senator John McCain, Heidi Klum
- Episode 95: Martha Stewart, Michael Bublé
- Episode 96: Geena Davis, INXS
- Episode 97: Julianne Moore, Randy Jackson, The O'Jays
- Episode 98: Charles Barkley, Catherine Keener
- Episode 99: Jimmy Fallon, Hannah Teter, She Wants Revenge
- Episode 100: Donald Trump, Bill Burr
- Episode 101: Marcia Cross, Daytona 500 Winner
- Episode 102: Matthew Fox, Brian Regan, Broadway's Jersey Boys
- Episode 103: Philip Seymour Hoffman, The Teutuls
- Episode 104: Amanda Peet, Jack Hanna
- Episode 105: Hugh Laurie, Ne-Yo
- Episode 106: Bruce Willis, The Strokes
- Episode 107: Barbara Walters, Tyler James Williams
- Episode 108: Sarah Jessica Parker
- Episode 109: Harry Connick Jr., Clap Your Hands Say Yeah
- Episode 110: Ricky Gervais, The Subways
- Episode 111: Emma Thompson, Frank Caliendo, Beth Orton
- Episode 112: Howard Stern, Carrie Underwood
- Episode 113: Natalie Portman, Al Franken
- Episode 114: Vin Diesel, Trey Parker & Matt Stone
- Episode 115: Denzel Washington, Diablo Cody
- Episode 116: Marcia Cross, Jenny Lewis and the Watson Twins
- Episode 117: David Spade, Teddy Geiger
- Episode 118: Sharon Stone, Mark Fainaru-Wada, Lance Williams
- Episode 119: Ray Romano, Willie Nelson
- Episode 120: Josh Hartnett, Chris Elliott, Yeah Yeah Yeahs
- Episode 121: Antonio Banderas, Patrice Oneal, Flaming Lips
- Episode 122: Liza Minnelli, Al Lubel
- Episode 123: Billy Crystal, Johnny Damon
- Episode 124: Geena Davis, Aaron Eckhart, Sonya Kitchell
- Episode 125: Jason Randal, Mandy Moore, Ben Harper
- Episode 126: Julia Louis-Dreyfus, Tyler Perry, Death Cab For Cutie
- Episode 127: Paul Rudd, Gretchen Mol, Mary J. Blige
- Episode 128: Eva Longoria, Barry Sonnenfeld
- Episode 129: Jane Fonda, Shooter Jennings
- Episode 130: Craig Furguson, Alexis Bledel, Tom Russell
- Episode 131: Piedmont Bird Callers, Michael Douglas, Emmylou Harris, Mark Knopfler
- Episode 132: Kerri Russell, Jerry Lee Lewis, Human Cannonball Team
- Episode 133: Tom Hanks, Kanye West
- Episode 134: Tom Cruise, Jamie Oliver
- Episode 135: Rosie Perez, Danica Patrick
- Episode 136: Julia Roberts, Pearl Jam
- Episode 137: Vince Vaughn, K.T. Tunstall
- Episode 138: Derek Jeter, Michelle Monghan, Barnum & Bailey Circus
- Episode 139: Kurt Russell, The Little Willies
- Episode 140: Jason Lee, Jack Hanna
- Episode 141: Teri Hatcher, Tom Dreesen, Michel Lauziere
- Episode 142: Edie Falco, Pete Correale, Van Hunt
- Episode 143: Kid Scientists, William Shatner, Angels & Airwaves
- Episode 144: Debra Messing, Chris Russo
- Episode 145: Bruce Willis, Goldfrapp
- Episode 146: Stupid Pet Tricks, Rebecca Romijn, Eagles of Death Metal
- Episode 147: Jennifer Garner, Harry Hill
- Episode 148: Martha Stewart, Dixie Chicks, Criss Angel
- Episode 149: Martin Short, James Blunt
- Episode 150: Jennifer Aniston, Rob Zombie
- Episode 151: Halle Berry, Harold Perrineau, Jesse James
- Episode 152: Bill Maher, Rita Wilson
- Episode 153: Lindsay Lohan, Sam Hornish Jr.
- Episode 154: Bonnie Hunt, Elvis Costello, Allen Toussaint
- Episode 155: Kyra Sedgwick, Al Franken
- Episode 156: Meredith Vieira, Jeremy Piven, My Morning Jacket
- Episode 157: Michael Keaton, Wolfmother
- Episode 158: Paris Hilton, Will Shortz
- Episode 159: Tim Russert, Cat Power
- Episode 160: Stephen Colbert, Mark Cuban, Neko Case
- Episode 161: Sandra Bullock, Widespread Panic
- Episode 162: Robert Duvall, Tommy Tiernan, Sonic Youth
- Episode 163: Adam Sandler, Julie Chen
- Episode 164: Nicole Richie, Brandon Routh
- Episode 165: Dwyane Wade, Amy Sedaris, Morningwood
- Episode 166: Meryl Streep, Yellowcard
- Episode 167: Al Gore, Rock Kills Kid
- Episode 168: Kevin Spacey, The Streets
- Episode 169: Anne Hathaway, Jim Gaffigan, Dashboard Confessional
- Episode 170: Robert Downey Jr., Fred Willard, Martha Wainwright
- Episode 171: Johnny Depp, Broken Social Scene
- Episode 172: Tom Brokaw, Paul Simon
- Episode 173: John Witherspoon, The Fray
- Episode 174: Paul Reubens, Yunjin Kim, Nelly Furtado
- Episode 175: Denis Leary, New York Met David Wright, the Wreckers
- Episode 176: Luke Wilson, Band of Horses
- Episode 177: Anderson Cooper, Greg Fitzsimmons
- Episode 178: Kate Hudson, Patrice O'Neal
- Episode 179: Regis Philbin, Bryce Dallas Howard
- Episode 180: Uma Thurman, Morgan Spurlock, egg catchers Brad Freeman and Patrick Breault
- Episode 181: Martin Short, Pink
- Episode 182: Donald Trump, Nick Griffin, Sam Roberts
- Episode 183: Colin Farrell, India.Arie
- Episode 184: Greg Kinnear, reptile expert Dr. Darrel Frost, Tapes 'n Tapes
- Episode 185: Scarlett Johansson, Paul Teutul Jr. and Sr.
- Episode 186: Johnny Depp, the Spinners
- Episode 187: Jamie Foxx, Tom Dreesen
- Episode 188: Samuel L. Jackson, Gnarls Barkley
- Episode 189: Hilary Duff, Jason Randal, Dirty Pretty Things
- Episode 190: Jessica Biel, Christina Aguilera
- Episode 191: Whoopi Goldberg, sock puppeteer Jack Fisett, Fatboy Slim
- Episode 192: Edward Norton, Greg Fitzsimmons
- Episode 193: Julianna Margulies, Andy Sansone, Outkast
- Episode 194: Chris Elliott, Rep. Nancy Pelosi, Razorlight
- Episode 195: John McEnroe, Artie Lang, Busta Rhymes
- Episode 196: Mark Wahlberg, Ruth Regina, M. Ward
- Episode 197: Maggie Gyllenhaal, Albert Pujols
Late Show with David Letterman - Season 13 Episode 104 : Amanda Peet, Jack Hanna
Amanda Peet and Jack Hanna are featured guests plus Peter Griffin of Family Guy presents the Top Ten!
