Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Andy Kindler, motocross demo with Travis Pastrana, Baby Gramps
- Episode 2: Zach Braff, Jeff Brendenburg, The Roots
- Episode 3: Snoop Dogg, Charlie Hill, OK Go
- Episode 4: Julianne Moore, radio-show hosts Opie and Anthony
- Episode 5: Al Franken, Todd Snider
- Episode 6: Maria Sharapova, Martha Stewart, Justin Timberlake
- Episode 7: Ashton Kutcher, Sam Hornish, Jr., TV on the Radio
- Episode 8: Dwayne "The Rock" Johnson, Norm MacDonald
- Episode 9: Anne Heche, Luke Ravenstahl, The Who
- Episode 10: Johnny Knoxville, Rachael Ray
- Episode 11: Dr. Phil McGraw, Willie Tyler and Lester, Sekou Bunch
- Episode 12: Patrick Dempsey, Jay Johnson and Darwin, Kasabian
- Episode 13: Marg Helgenberger, Ronn Lucas and Scorch, Diana Krall
- Episode 14: Ted Turner, Jeff Dunham and Walter, Fergie
- Episode 15: LeBron James, Todd Oliver and Irving, Ludacris
- Episode 16: Ray Liotta, Elvis Costello & Tony Bennett, Billy Garcia
- Episode 17: Billy Bob Thornton, Lily Capehart, Sean Lennon
- Episode 18: Amanda Peet, Nigella Lawson, Bob Seger
- Episode 19: Sir Richard Branson, Dane Cook, Monica
- Episode 20: Nathan Lane, Jeff Caldwell
- Episode 21: Pete Rose, Roy Wood Jr., Cecilia Mansilla
- Episode 22: Andy Dick, Keith Olbermann, Brazilian Girls
- Episode 23: Alec Baldwin, Vladae the Dog Wizard, Jerry Lee Lewis & Neil Young
- Episode 24: Frank Caliendo, Rachael Harris, Xzibit, Phil Pfister
- Episode 25: Amy Sedaris, Trey Anastasio
- Episode 26: Robin Williams, J.P. Calderon, Sam Moore with Wynonna
- Episode 27: Nicky Hilton, Bob Woodward, Joseph Arthur
- Episode 28: Jon Stewart, Nick Lachey
- Episode 29: Katie Couric, Brian Kiley, Alan Jackson
- Episode 30: Diddy, Neil Patrick Harris
- Episode 31: Tom Arnold, Brian Regan, the latest "Survivor: Cook Islands" castaway
- Episode 32: Tina Fey, Mike Golic & Mike Greenberg, The Killers
- Episode 33: Julia Louis-Dreyfus, Jay Thomas, John Legend
- Episode 34: Tim Robbins, Gene Rurka, Russell Thompkins Jr. and The New Stylistics
- Episode 35: Bill O'Reilly, Jeff Altman, Tilly and the Wall
- Episode 36: Borat, Tiki Barber, Beck
- Episode 37: Rachel Weisz, David Rakoff, Morningwood
- Episode 38: Gary Sinise, Joanne Carson, Jim Norton
- Episode 39: Rosie O'Donnell, Lady Sovereign
- Episode 40: Martin Short, Kinky Friedman
- Episode 41: Will Ferrell, Jack Hanna
- Episode 42: Dustin Hoffman, Jamie Oliver, The Metropolitan Opera
- Episode 43: Kiefer Sutherland, Jenna Fischer, Rocco DeLuca
- Episode 44: Daniel Craig, documentary film subject Teri Horton, Elvis Costello, Rosanne Cash
- Episode 45: Robin Williams, Rich Little, George Jones
- Episode 46: Jack Black & Kyle Gass, Fred Travalena, Tenacious D
- Episode 47: Ellen DeGeneres, Gordie Brown, +44
- Episode 48: Christopher Guest, Frank Caliendo, The Game
- Episode 49: Sen. John Edwards, Kevin Pollak, Will Arnett
- Episode 50: Jerry Seinfeld, Dan Patrick
- Episode 51: Hugh Jackman, Chris Elliott, Jimmie Johnson
- Episode 52: Matthew Broderick, Lupe Fiasco & Jill Scott
- Episode 53: Eugene Levy, John Mayer
- Episode 54: Helen Hunt, DJ Shadow, Q-Tip and Lateef
- Episode 55: Kate Winslet, Tom Waits
- Episode 56: George Clooney, The Decemberists
- Episode 57: Richard Simmons, Kate Walsh, Ciara
- Episode 58: Jennifer Connelly, Tom Dreesen, Shiny Toy Guns
- Episode 59: Danny DeVito, 16-year-old duct tape expert William Beacom, Silversun Pickups
- Episode 60: Matt Damon, Barbara Walters
- Episode 61: Howard Stern, Gwen Stefani
- Episode 62: Kid Scientists, Regis Philbin, Robert Randolph
- Episode 63: Will Smith, Evanescence
- Episode 64: Clint Eastwood, Matthew Fox
- Episode 65: Frank Caliendo as John Madden, Ben Stiller, Rodrigo & Gabriela
- Episode 66: Beyonce, Marv Albert, The Dears
- Episode 67: Renée Zellweger, holiday toy demonstration, Taking Back Sunday
- Episode 68: Tom Brokaw, Cold War Kids
- Episode 69: Cate Blanchett, Jay Thomas, Darlene Love
- Episode 70: Martin Short, Donal Logue
- Episode 71: Matt Lauer, Artie Lange, Augustana
- Episode 72: Cedric the Entertainer, Wesley Autrey, Switchfoot
- Episode 73: Donald Trump, Mary Lynn Rajskub
- Episode 74: David Arquette, Jennifer Hudson
- Episode 75: Penelope Cruz, Gary Mule Deer, Ben E. King
- Episode 76: Peter O'Toole, Marc Maron
- Episode 77: Julianne Moore, Madonna, The Hold Steady
- Episode 78: Kristin Chenoweth, John Witherspoon, Josh Ritter
- Episode 79: Amy Sedaris, Jason Randal, America with Ryan Adams & Ben Kweller
- Episode 80: Paul Newman, Sebastian Bourdais, Diana Ross
- Episode 81: Tina Fey, Terri and Bindi Irwin
- Episode 82: Harry Shearer, Vera Farmiga, Mat Kearney
- Episode 83: Dan Rather, Tricia Helfer, Andy Kindler
- Episode 84: Kevin Spacey, Alicia Keys, Nellie McKay & The Brooklyn Philharmonic
- Episode 85: Ricky Gervais, Forest Whitaker, The Shins
- Episode 86: Frank Caliendo, Mandy Moore, Rosanne Cash
- Episode 87: Bill Murray, LeBron James
- Episode 88: David Spade, Alexandra Pelosi, Dustin Kensrue
- Episode 89: Dr. Phil McGraw, Fall Out Boy
- Episode 90: Randy Jackson, Harry Connick Jr., Regis
- Episode 91: Chris Elliott, Kelly Ripa, John Mellencamp
- Episode 92: Jack Hanna, Katherine Heigl, Patty Griffin
- Episode 93: Rachael Ray, Frank Caliendo, The Fab Faux
- Episode 94: Drew Barrymore, Rickie Lee Jones, Kevin Johnson with Clyde & Matilda
- Episode 95: Peyton Manning, Dan Horn with Orson, The Cat Empire
- Episode 96: Martha Stewart, Otto Petersen with George, Norah Jones
- Episode 97: Sienna Miller, NAS, Jim Barber with Seville
- Episode 98: Tracy Morgan, Gabrielle Union, Brad Cummings and Rex
- Episode 99: Jim Carrey, Daytona 500 winner Kevin Harvick
- Episode 100: Barbara Walters, David Neeleman, K-os
- Episode 101: John Travolta, Eric Nerhus, a performance from the Broadway musical "Spring Awakening"
- Episode 102: Billy Bob Thornton, Rashida Jones, Barenaked Ladies
- Episode 103: Samuel L. Jackson, Jim Gaffigan
- Episode 104: Jake Gyllenhaal, Brand New
- Episode 105: Evangeline Lilly, Jeff MacGregor, bubble blowing guy Tom Noddy
- Episode 106: Sen. John McCain, Robin Thicke
- Episode 107: Bob Woodruff, John Mayer
- Episode 108: Charles Grodin, Dan Naturman
- Episode 109: Chris Rock, Sandra Oh, Amy Winehouse
- Episode 110: Jeff Goldblum, Barbara McQueen
- Episode 111: Richard Gere, Explorers Club chef Gene Rurka, Aqualung
- Episode 112: Bernie Mac, Paula Abdul, Joss Stone
- Episode 113: Adam Sandler, Don Cheadle, Danica Patrick, Todd Barry, Lucinda Williams
- Episode 114: Jack Black, Lara Logan, beer launching refrigerator creator John Cornwell
- Episode 115: Will Ferrell, Kings of Leon, Rachel Smith
- Episode 116: Patricia Arquette, Paul Mooney, Macy Gray
- Episode 117: Al Franken, Isla Fisher
- Episode 118: Rosario Dawson, Bloc Party, Piedmont bird callers
- Episode 119: Donald Trump, Jon Heder
- Episode 120: Sen. Barack Obama, Halle Berry, Zach Johnson
- Episode 121: David Duchovny, Ryan Howard, Andrew Bird
- Episode 122: Alec Baldwin, Debbie Parkhurst and her dog Toby, LCD Soundsystem
- Episode 123: Bruce Willis, Jason Randal
- Episode 124: Bill Cosby, Angela Kinsey
- Episode 125: Kelly Ripa, Simon Pegg
- Episode 126: Craig Ferguson, Dave Della Terza, Avril Lavigne
- Episode 127: Edie Falco, Paul Scheer, Son Volt
- Episode 128: Garry Shandling, Paul Teutul Sr. and Jr., Tokyo Police Club
- Episode 129: Jessica Biel, Ira Glass, Regina Spektor
- Episode 130: Brian Williams, Steven Wright, a Top Ten list presented by Sanjaya Malakar
- Episode 131: David Hyde Pierce, Ivanka Trump, Corinne Bailey Rae
- Episode 132: Nicolas Cage, Barry Sonnenfeld, The Fratellis
- Episode 133: Steve Martin, Dave Cota and A.J. the parakeet, Derek Jeter
- Episode 134: Frank Caliendo as President George W. Bush, Andy Dick, Jarvis Cocker
- Episode 135: Kirsten Dunst, Rob Magnotti, Dinosaur Jr.
- Episode 136: Tobey Maguire, John Byner, Modest Mouse
- Episode 137: Drew Barrymore, Mike MacRae, Ben Kweller
- Episode 138: Marcia Cross, Joe Piscopo, Tori Amos
- Episode 139: Ray Romano, Reggie Reg, Dennis Haysbert
- Episode 140: Regis Philbin, Darlene Love
- Episode 141: Jane Fonda, Tom Ruprecht, Kelly Clarkson
- Episode 142: Lindsay Lohan, Tom Dreesen, The Kooks
- Episode 143: Dr. Phil McGraw, Jack Hanna
- Episode 144: Charles Grodin, Jake Johannsen
- Episode 145: Mike Myers, America Ferrera
- Episode 146: Don Rickles, Michael Imperioli, Wilco, a Top Ten List presented by Masi Oka
- Episode 147: Ricky Gervais, Mary Lynn Rajskub, Mavis Staples, a Top Ten List presented by Bob Barker
- Episode 148: Kid Scientists, Luke Wilson, Rufus Wainwright, a Top Ten List presented by Homer Simpson
- Episode 149: Teri Hatcher, Jonah Hill, Elvis Costello
- Episode 150: Rudolph Giuliani, Mike West, Jesus & Mary Chain
- Episode 151: Charles Barkley, Seth Rogen, Michael Martin Murphey
- Episode 152: Stupid Pet Tricks, Rosie Perez, Dr. Dog
- Episode 153: Al Gore, Jim Short
- Episode 154: Kevin Spacey, Alexis Bledel
- Episode 155: Matt Damon, Indianapolis 500 winner Dario Franchitti, Bright Eyes
- Episode 156: Chevy Chase, Amanda Beard, Satellite Party
- Episode 157: Nicole Richie, Artie Lange, Chrisette Michele
- Episode 158: Amy Sedaris, Chuck "The Iceman" Liddell, Jordan Zevon
- Episode 159: Ellen Barkin, Brian Regan
- Episode 160: Denis Leary, Flight of the Conchords, Neal Seaver
- Episode 161: Kyra Sedgwick, Sir Richard Branson, Maroon 5
- Episode 162: Bear Grylls, Jeremy Piven, Elvis Perkins
- Episode 163: John Cusack, Pink Martini, Turkey Gobbling Champions
- Episode 164: Michael Moore, Bill Burr
- Episode 165: Bruce Willis, Tony Parker, diving dogs
- Episode 166: Amanda Peet, John Krasinski, Bryan Ferry
- Episode 167: Claire Danes, Dan Patrick & Keith Olbermann, Ryan Adams & The Cardinals
- Episode 168: Robin Williams, Julie Chen
- Episode 169: Dennis Kucinich, Shia LaBeouf, Morrissey
- Episode 170: Don Cheadle, Smashing Pumpkins, Venus Williams
- Episode 171: Sienna Miller, Michael Cera, Interpol
- Episode 172: Diddy, Emma Watson, Spoon
- Episode 173: Paul Teutul Sr. and Jr., Vera Farmiga, Joe Matarese
- Episode 174: Queen Latifah, Alan Zweibel, Smashing Pumpkins
- Episode 175: Michelle Pfeiffer, Jonah Hill, Michel Lauziere
- Episode 176: Adam Sandler, Mike Golic and Mike Greenberg, Mute Math
- Episode 177: John Travolta, Paula Abdul, Teddy Thompson
- Episode 178: Kevin James, Jose Andres, White Rabbits
- Episode 179: Julia Stiles, Pete Jordan, Nick Griffin
- Episode 180: Drew Carey, Nikki Blonsky, Grinderman
- Episode 181: Paul Rudd, Tony Dungy, The National
- Episode 182: Catherine Zeta-Jones, Bob Sarlatte, Porter Wagoner
- Episode 183: Sharon Osbourne, Brian Kiley, Yeah Yeah Yeahs
- Episode 184: Anne Hathaway, Jim Gaffigan, Buffalo Tom
- Episode 185: Andy Samberg, Catherine Bell, The Bravery
- Episode 186: Sen. Joe Biden, Seth Rogen, Gogol Bordello
- Episode 187: Matt Damon, Jeff Altman, Angelique Kidjo
- Episode 188: Jackie Chan, Chelsea Handler, Michael Buble
- Episode 189: Glenn Close, Judd Apatow, Chris & Rich Robinson
- Episode 190: Jeff Goldblum, Hayden Panettiere, New Pornographers
- Episode 191: Samuel L. Jackson, Christiane Amanpour, Tom Russell
- Episode 192: Richard Gere, Tom Dreesen, Velvet Revolver
- Episode 193: Tina Fey, Venus Williams, Steve Earle
- Episode 194: Tom Arnold, Kristin Gore, Jim McDonald
- Episode 195: Susan Sarandon, Rick Reilly, Feist
- Episode 196: Kevin Bacon, Kat Von D, T.I. with Wyclef
- Episode 197: Ellen DeGeneres, Jeff Garlin, Against Me!
- Episode 198: Sen. Hillary Rodham Clinton, Willie Nelson & Kenny Chesney
- Episode 199: Amy Sedaris, Will Arnett
Late Show with David Letterman - Season 14 Episode 68 : Tom Brokaw, Cold War Kids
Tom Brokaw and Cold War Kids are the scheduled guests.
