Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Nicolas Cage, Anna Torv, Terrence Howard
- Episode 2: Dr. Phil McGraw, Tilda Swinton, Tricky
- Episode 3: Robin Williams, Shannen Doherty, Duffy
- Episode 4: John Malkovich, Hayden Panettiere, Steve Earle
- Episode 5: Keira Knightley, Thomas L. Friedman
- Episode 6: Jada Pinkett Smith, Chris Russo, Michael Buble
- Episode 7: Sen. Barack Obama, LeBron James
- Episode 8: Jessica Simpson, Jack Hanna
- Episode 9: Meg Ryan, Ricky Gervais
- Episode 10: Bill Clinton, Chris Rock
- Episode 11: Julianne Moore, Tom Dreesen & Tim Reid, Kings of Leon
- Episode 12: Keith Olbermann, Chandra Wilson, Delta Goodrem
- Episode 13: Paris Hilton, Usain Bolt, Morningwood
- Episode 14: Lance Armstrong, Kristen Wiig, TV on the Radio
- Episode 15: Julia Louis-Dreyfus, Michael Cera, Pete Seeger
- Episode 16: Anne Hathaway, Josette Sheeran, The Virgins
- Episode 17: Kate Walsh, Barry Sonnenfeld, Darius Rucker
- Episode 18: Calista Flockhart, Bill Hader, Lucinda Williams
- Episode 19: Brian Williams, Tim Robbins
- Episode 20: Russell Crowe, Sarah Vowell, The Pretenders
- Episode 21: Debra Messing, John Carter, Tegan & Sara
- Episode 22: Dennis Quaid, Sarah Chalke, Buddy Guy
- Episode 23: Bill Murray, Beck
- Episode 24: Jeremy Piven, Elizabeth Banks, Lou Reed
- Episode 25: Sarah Silverman, the Teutuls, Ra Ra Riot
- Episode 26: Josh Brolin, Amy Sedaris, Blues Traveler
- Episode 27: Martin Short, Marv Albert
- Episode 28: Sen. John McCain, Ne-Yo
- Episode 29: Tina Fey, Frank Caliendo, Tim Montana
- Episode 30: Bill O'Reilly, Lauren Conrad
- Episode 31: Regis Philbin, James Taylor
- Episode 32: Alec Baldwin, Paul Mooney, Ryan Adams
- Episode 33: Ashley Olsen, Paul Rudd, John Legend
- Episode 34: Marcia Cross, Alan Zweibel
- Episode 35: Paris Hilton, Elvis Costello, Jenny Lewis, a Top Ten List by Ricky Gervais
- Episode 36: Tom Brokaw, Vera Farmiga
- Episode 37: Ben Stiller, Q-Tip
- Episode 38: Natalie Portman, Artie Lange, Brad Paisley
- Episode 39: Ted Turner, Jamie Oliver, Taylor Swift
- Episode 40: Don Rickles, Amy Brenneman, Alicia Keys
- Episode 41: Russell Brand, Charlie Haden
- Episode 42: Bruce Willis, Sia
- Episode 43: Bill Cosby, Matt Braunger
- Episode 44: Emma Thompson, Michelle Felicetta, Purple Reign
- Episode 45: Carla Bruni Sarkozy, Jack Hanna, Cold Hard Cash
- Episode 46: Katie Couric, Dev Patel, Mr. Brownstone
- Episode 47: Stephen Colbert, Kristen Stewart, Super Diamond
- Episode 48: James Franco, Bruce McCall, The Allstarz
- Episode 49: Nicole Kidman, Simon Baker, Kanye West
- Episode 50: Reese Witherspoon, Harry Connick Jr.
- Episode 51: Teri Hatcher, Ludacris
- Episode 52: Denis Leary, John Mayer
- Episode 53: Tom Arnold, Faith Hill
- Episode 54: Jennifer Connelly, Anderson Cooper, The Duke Spirit
- Episode 55: Amy Adams, Michael Sheen, Jamey Johnson
- Episode 56: Keanu Reeves, Paula Abdul, Loudon Wainwright III
- Episode 57: Sen. John McCain, Bon Iver
- Episode 58: Meryl Streep, Jeff Altman
- Episode 59: Adam Sandler
- Episode 60: Tom Cruise, Fall Out Boy
- Episode 61: Jennifer Aniston, Broken Social Scene
- Episode 62: Will Smith, Of Montreal
- Episode 63: Jerry Seinfeld, Leona Lewis
- Episode 64: Dustin Hoffman, Todd Rundgren
- Episode 65: Jay Thomas, Mickey Rourke, Darlene Love
- Episode 66: Tracy Morgan, Matt Braunger
- Episode 67: Kate Hudson, Glasvegas
- Episode 68: Kevin James, Becky Quick, Erin McCarley
- Episode 69: Ricky Gervais, Rose Byrne, Okkervil River
- Episode 70: Kate Winslet, Marv Albert
- Episode 71: Kiefer Sutherland, Wendy Liebman
- Episode 72: Billy Crystal, Kara DioGuardi
- Episode 73: Salma Hayek, Jimmie Walker
- Episode 74: Clint Eastwood, Randy Rogers Band
- Episode 75: Kyra Sedgwick, Gwen Ifill
- Episode 76: Zach Braff, Arj Barker, The Airborne Toxic Event
- Episode 77: Brian Williams, Ben Kweller
- Episode 78: Evangeline Lilly, Seth Meyers, Andrew Bird
- Episode 79: Lauren Graham, Guy Fieri, MENEW
- Episode 80: Renee Zellweger, Tony Dungy, Graham Nash sits in with the band
- Episode 81: Mary Hicks, the Gaslight Anthem
- Episode 82: Ben Roethlisberger, Steve Martin
- Episode 83: Rod Blagojevich, Richard Jenkins
- Episode 84: Joe Torre, Demetri Martin, Lyle Lovett and John Hiatt
- Episode 85: Isla Fisher, extreme fisherman Matt Watson, Mark Olson and Gary Louris, a Top Ten List presented by Lil' Wayne
- Episode 86: Dakota Fanning, Keith Alberstadt, Beirut
- Episode 87: Naomi Watts, Danny McBride, 2009 Sports Illustrated Swimsuit Issue cover reveal
- Episode 88: The crew of US Airways "Miracle On The Hudson" Flight 1549, Heartless Bastards
- Episode 89: Joaquin Phoenix, Bar Refaeli, Anthony Hamilton
- Episode 90: Chris Russo, the Jonas Brothers, Ashford & Simpson
- Episode 91: Martha Stewart, Jake Johannsen, Matt Nathanson
- Episode 92: Ellen Pompeo, Daytona 500 winner Matt Kenseth, Willie Nelson with Asleep at the Wheel
- Episode 93: Bonnie Hunt, M. Ward
- Episode 94: Donald Trump, Antony and the Johnsons
- Episode 95: David Spade, Jeffrey Sachs, David Sanborn with Sam Moore
- Episode 96: Barbara Walters, Mike Birbiglia, Shemekia Copeland
- Episode 97: Katie Couric, U2
- Episode 98: Felicity Huffman, Artie Lange, U2
- Episode 99: Dr. Phil McGraw, U2
- Episode 100: Jon Stewart, U2, a Top Ten List featuring 10 Team USA members from the World Baseball Classic
- Episode 101: Jason Segel, Brian Kiley, U2
- Episode 102: Russell Brand, Jack Hanna
- Episode 103: Stupid Pet Tricks, Paul Rudd, Razorlight
- Episode 104: Tom Brokaw, An Horse
- Episode 105: Andy Samberg, Paul Teutul Sr., the Broadway cast of "West Side Story"
- Episode 106: Will Ferrell, Cursive
- Episode 107: Nicolas Cage, Rachel Maddow
- Episode 108: Julia Roberts, Bell X1
- Episode 109: Craig Ferguson, Ginnifer Goodwin, Modest Mouse
- Episode 110: Billy Crystal, Kara DioGuardi, a Top Ten List presented by Owen Wilson
- Episode 111: David Spade, Richard Zoglin, David Sanborn and Sam Moore
- Episode 112: Hugh Laurie, Bloc Party
- Episode 113: Mary Tyler Moore, Blake Lively, White Lies
- Episode 114: Christina Applegate, Jim Gaffigan, Jesse Harris with Norah Jones
- Episode 115: Seth Rogen, Tom Dreesen, Adele
- Episode 116: Bill O'Reilly, Marianne Faithfull
- Episode 117: Marg Helgenberger, Francisco Palacios, Ray LaMontagne
- Episode 118: Michael J. Fox, the Fray
- Episode 119: Denis Leary, Diana Krall
- Episode 120: Zac Efron, Mike Golic and Mike Greenberg, A.C. Newman with Nicole Atkins
- Episode 121: Kelly Ripa, Bill Scheft, Yeah Yeah Yeahs
- Episode 122: Drew Barrymore, Jack McBrayer, Neko Case
- Episode 123: Matthew Perry, Elisha Cuthbert, Rascal Flatts
- Episode 124: Russell Crowe, Joe Wong
- Episode 125: Jeff Goldblum, Jeff Dunham
- Episode 126: Nathan Lane, Tinted Windows
- Episode 127: Beyonce, Jim Parsons
- Episode 128: Jamie Foxx, Lauren Conrad, the Dead
- Episode 129: Michael Keaton, Lily Allen
- Episode 130: Matthew Fox, Carol Leifer, the All-American Rejects, a Top Ten List presented by Matthew Stafford
- Episode 131: Dolly Parton, Zachary Quinto
- Episode 132: Jennifer Garner, Tesla Motors CEO Elon Musk, Manchester Orchestra
- Episode 133: Regis Philbin, a performance by the Broadway cast of "Hair"
- Episode 134: Kiefer Sutherland, Jim Norton, Bat for Lashes
- Episode 135: Gordon Ramsay, Chris Pine, Keri Hilson with Kanye West
- Episode 136: Liev Schreiber, Dr. Sanjay Gupta, Franz Ferdinand
- Episode 137: Bruce Willis, Ben Harper & Relentless7
- Episode 138: Norm MacDonald, a Top Ten List presented by Leonard Nimoy, Animal Collective
- Episode 139: Matthew Broderick, Brian Regan, Chris Cornell
- Episode 140: Tom Hanks, the Killers
- Episode 141: Alec Baldwin, Maya Rudolph, Chrisette Michele
- Episode 142: Robin Williams, Wynton Marsalis
- Episode 143: Kid Scientists, Teri Hatcher, Rick Ross with Magazeen, a Top Ten List presented by Ron Howard
- Episode 144: John Goodman, Tommy Tiernan, Mastodon
- Episode 145: Ben Stiller, White Rabbits
- Episode 146: Jane Fonda, Piedmont Bird Callers, Kenny Chesney
- Episode 147: Stephen Colbert, General Motors Vice Chairman Bob Lutz, Grizzly Bear
- Episode 148: Amy Sedaris, Ed Helms, Jean Redpath
- Episode 149: Ricky Gervais, Green Day
- Episode 150: Bill Cosby, Helio Castroneves, Melody Gardot
- Episode 151: Jack Hanna, John Krasinski
- Episode 152: Jessica Biel, Zach Galifianakis, Steve Earle
- Episode 153: Elvis Costello, a Top Ten List presented by Neil Patrick Harris
- Episode 154: Paris Hilton, Calvin Borel, Steven Wright
- Episode 155: Howard Stern, Mos Def
- Episode 156: Julia Roberts, Black Eyed Peas
- Episode 157: Kathy Griffin, Stupid Human Tricks, Sonic Youth, an NBA Finals report by Phoenix Suns' Steve Nash
- Episode 158: Denzel Washington, the Jonas Brothers, a Top Ten List with Regis Philbin
- Episode 159: Sandra Bullock, Pete Correale, P.J. Harvey & John Parish
- Episode 160: Jack Black, M.A. Sanjayan
- Episode 161: Michelle Pfeiffer, Judah Friedlander, Ian McLagan & the Bump Band
- Episode 162: Ryan Reynolds, Padma Lakshmi, the Eels
- Episode 163: Danny DeVito, Bear Grylls, Phoenix
- Episode 164: Jada Pinkett Smith, Michael Cera, the Sounds
- Episode 165: Samuel L. Jackson, Emeril Lagasse, Iggy Pop & the Brighton Port Authority
- Episode 166: Sandra Day O'Connor, MSTRKRFT with John Legend, a Top Ten List presented by Lucas Glover
- Episode 167: Ray Romano, St. Vincent
- Episode 168: Johnny Depp, Megan Fox
- Episode 169: Martin Short, Regina Spektor
- Episode 170: Serena Williams, Hayden Panettiere, Conor Oberst and the Mystic Valley Band
- Episode 171: Sacha Baron Cohen, Joel McHale
- Episode 172: Queen Latifah, Emma Watson
- Episode 173: Daniel Radcliffe, Veronika Part, Levon Helm, a Top Ten List presented by Bruno
- Episode 174: Rainn Wilson, Larry Miller, Maxwell
- Episode 175: Jonah Hill, Gar Ryness, Kelly Clarkson
- Episode 176: Edie Falco, Michael Showalter, Wilco with Feist
- Episode 177: Paul McCartney, a Top Ten List presented by Bruce Willis
- Episode 178: Anderson Cooper, Anna Paquin, Grizzly Bear
- Episode 179: Tom Arnold, Metric, a Top Ten List presented by Dave's mom Dorothy
- Episode 180: Katherine Heigl, Jeff Altman, Spinnerette
- Episode 181: Kevin Spacey, Jesse James, the Flatlanders, a Top Ten List presented by Stewart Cink
- Episode 182: Tracy Morgan, Leslie Mann, Diane Birch
- Episode 183: Sean "Diddy" Combs, Vera Farmiga, Ginuwine with Missy Elliott
- Episode 184: Amy Poehler, Nick Griffin, Judy Collins
- Episode 185: Eric Bana, Dave Matthews Band, a Top Ten List presented by Chicago White Sox star Mark Buehrle
- Episode 186: Katie Couric, Silversun Pickups
- Episode 187: Amy Adams, Tom Dreesen, Elbow
- Episode 188: Adam Sandler, Cage the Elephant
- Episode 189: Regis Philbin, Ted Alexandro, Dave Matthews Band
- Episode 190: Quentin Tarantino, Eric Ripert, Robert Cray
- Episode 191: Donald Trump, Diane Kruger, Billy Currington, a Top Ten List presented by Britney Spears
- Episode 192: Mike Myers, Ken Burns
- Episode 193: Anna Wintour, Mark Teixeira
- Episode 194: Renee Zellweger, Gary Mule Deer
- Episode 195: Christina Applegate, Brendan Benson, Patton Oswalt
- Episode 196: Anna Wintour, Mark Teixeira
- Episode 197: Mary-Louise Parker, Eugene Levy, Jet
- Episode 198: Anne Heche, Jim Parsons, Care Bears on Fire
- Episode 199: Andy Roddick, Rachael Ray, Mutemath
- Episode 200: Artie Lange, Todd Barry, Imogen Heap
Late Show with David Letterman - Season 16 Episode 66 : Tracy Morgan, Matt Braunger
Dave shows a (phony) clip of Larry King interviewing the shoe that was thrown at President Bush; Tracy Morgan jokes about his recent legal troubles; Dave asks Paul about how he spent his Christmas; "MADtv" star Matt Braunger makes his television stand-up debut.
