Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Will Arnett, Lisa Lampanelli, Guided by Voices
- Episode 2: Brian Williams, WU LYF
- Episode 3: Tina Fey, Jeremy Irvine, Barr Brothers
- Episode 4: Kristen Bell, Dan Naturman, Blind Pilot
- Episode 5: Mark Wahlberg, Heather Morris, Snow Patrol
- Episode 6: Kate Beckinsale, Marv Albert, The Little Willies
- Episode 7: Dolly Parton, Alan Zweibel
- Episode 8: Sen. John McCain, Johnny Winter
- Episode 9: Viggo Mortensen, Dennis Regan, Tony Bennett
- Episode 10: Simon Baker, Elizabeth Banks, Seal
- Episode 11: Ricky Gervais, Jessica Chastain, Kathleen Edwards
- Episode 12: Marg Helgenberger, Michael Fassbender, Ellie Goulding
- Episode 13: Kathy Griffin, Simon Helberg, Joseph Arthur
- Episode 14: Dana Carvey, Jon Fisch, Los Campesinos!
- Episode 15: Jennifer Lopez, Rob Schneider, James McCartney
- Episode 16: Bill Murray, Girls' Generation
- Episode 17: Howard Stern, The Airborne Toxic Event
- Episode 18: Woody Harrelson, Stephen Merchant, Lana Del Rey
- Episode 19: Michelle Williams, Jake Johannsen, Ziggy Marley
- Episode 20: Eli Manning, Sarah Michelle Gellar, Die Antwoord
- Episode 21: Denzel Washington, The Fray
- Episode 22: Ryan Reynolds, Ellie Kemper, Dierks Bentley
- Episode 23: Nicolas Cage, Michelle Dockery, The Kills
- Episode 24: David Spade, Betty Wright
- Episode 25: Reese Witherspoon, Michael Weatherly, Top Ten by Sports Illustrated Swimsuit models, Kasabian
- Episode 26: Viola Davis, the 2012 Sports Illustrated Swimsuit cover model, Mark Ronson, Erykah Badu, The Dap-Kings, Zigaboo Modeliste
- Episode 27: Jon Stewart, American Bagging Champion Stephanie Teteak, Yelawolf with Kid Rock
- Episode 28: Joan Rivers, Andrew Lincoln, Jason Mraz
- Episode 29: Kristen Wiig, Mike Birbiglia, Butch Walker and the Black Widows
- Episode 30: Jack Hanna, Jesse Tyler Ferguson
- Episode 31: Alec Baldwin, Eric Hutchinson
- Episode 32: Paul Rudd, John Witherspoon, Heartless Bastards
- Episode 33: Kristin Chenoweth, Joe Scarborough, K'naan featuring Nelly Furtado
- Episode 34: Matthew Broderick, Nick Griffin, We Are Augustines
- Episode 35: Ed Helms, Dan Patrick, Lyle Lovett
- Episode 36: Nathan Lane, Pauley Perrette, Estelle
- Episode 37: Neil Patrick Harris, Taylor Kitsch, Robert Glasper Experiment featuring Lupe Fiasco & Bilal
- Episode 38: Jon Hamm, Ted Alexandro, White Rabbits
- Episode 39: Will Ferrell, Jon Bernthal
- Episode 40: Amanda Peet, Nick Offerman, Top Ten by Cee-Lo Green, The Chieftains with the Low Anthem
- Episode 41: Martin Short, The Ting Tings
- Episode 42: Michelle Obama, Esperanza Spalding
- Episode 43: Jennifer Lawrence, Gail Collins, The Shins
- Episode 44: Debra Messing, Josh Hutcherson, Oberhofer
- Episode 45: Rachel Maddow, Timothy Olyphant, Train
- Episode 46: Jason Sudeikis, Lionel Richie, Jason Aldean
- Episode 47: Chris Elliott, Mohamed Nasheed, Justin Townes Earle
- Episode 48: Tracy Morgan, Jim Rome, The Broadway musical 'Once'
- Episode 49: Megan Mullally, Joe Wong, Band of Skulls
- Episode 50: Keith Olbermann, Allison Williams, Lukas Nelson & Promise of the Real
- Episode 51: Kiefer Sutherland, Eugene Levy, The Punch Brothers
- Episode 52: Ricky Gervais, Cobie Smulders, Tennis
- Episode 53: Sean Hayes, Shooter Jennings
- Episode 54: Magic Johnson, Larry Bird, Jim Gaffigan, Kaiser Chiefs
- Episode 55: Billy Crystal, Alabama Shakes
- Episode 56: Julia Louis-Dreyfus, Keith Alberstadt, Bonnie Raitt
- Episode 57: Jason Segel, Zach Wahls, Fun
- Episode 58: Amy Poehler, Wendy Williams, Trampled by Turtles
- Episode 59: Rob Lowe, Gov. Brian Schweitzer, The War on Drugs
- Episode 60: Robin Williams, Andrew Luck
- Episode 61: Madden NFL 13 Cover Calvin Johnson, Chris Hemsworth, Darrell Hammond, Miike Snow
- Episode 62: Don Rickles, Carrie Underwood
- Episode 63: Seth Meyers, Krysten Ritter, Father John Misty
- Episode 64: Stupid Pet Tricks, Johnny Galecki, Norah Jones
- Episode 65: Stephen Colbert, Chloe Grace Moretz, The cast of 'Nice Work If You Can Get It'
- Episode 66: Anderson Cooper, Yves Rossy, Electric Guest
- Episode 67: Dr. Phil McGraw, Beth Behrs, Spiritualized
- Episode 68: Jim Parsons, Mika Brzezinski, Macy Gray
- Episode 69: Eva Longoria, Tom Dreesen, Florence and The Machine
- Episode 70: Kid Scientists, Elizabeth Banks, Edward Sharpe & The Magnetic Zeros
- Episode 71: Jon Cryer, Tommy Johnagin, M. Ward
- Episode 72: Kelly Ripa, Adam Scott, Tenacious D
- Episode 73: Brian Williams, El-P
- Episode 74: Betty White, Moses Maddox, Best Coast
- Episode 75: Conan O'Brien, Regina Spektor, John Mayer
- Episode 76: Sacha Baron Cohen, Julie Chen, Beach House
- Episode 77: Lea Michele, Barry Sonnenfeld, Shaolin Warriors of Ringling Bros
- Episode 78: Will Smith, Gossip
- Episode 79: Piedmont Bird Callers, Bill O'Reilly, Pitbull
- Episode 80: Joan Rivers, Dario Franchitti, Silversun Pickups
- Episode 81: Neil Patrick Harris, Noomi Rapace, Alan Jackson
- Episode 82: Jane Fonda, Mayor of London Boris Johnson, Jimmy Cliff
- Episode 83: Bill Murray, The Temper Trap
- Episode 84: Mark Wahlberg, Sebastian Vettel, Black Box Revelation
- Episode 85: Jack Hanna, Patti Smith
- Episode 86: Adam Sandler, Jerry Douglas
- Episode 87: Regis Philbin, Lenny Marcus, Elizabeth Cook
- Episode 88: Denis Leary, Olivia Wilde, The Pierces
- Episode 89: Jeff Daniels, Benjamin Walker, Walk the Moon
- Episode 90: Alec Baldwin, Michael Kiwanuka
- Episode 91: Justin Bieber, Michael Ian Black
- Episode 92: Emma Stone, Jimmie Walker, Diamond Rugs
- Episode 93: LeBron James, Andrew Garfield, Maroon 5
- Episode 94: Channing Tatum, Scott Pelley, The Gaslight Anthem
- Episode 95: Blake Lively, Drew Brees
- Episode 96: Ray Romano, Tom Waits, Top Ten by American League All-Stars
- Episode 97: Queen Latifah, Fred Armisen, Cory Chisel and the Wandering Sons
- Episode 98: Bryan Cranston, R.A. Dickey, Zac Brown Band
- Episode 99: Anne Hathaway, Moody McCarthy, Loudon Wainwright III
- Episode 100: Morgan Freeman, Gallagher, Nas
- Episode 101: Roseanne Barr, Aubrey Plaza, Jeff the Brotherhood
- Episode 102: Kyra Sedgwick, Mike Golic and Greenberg, Red Wanting Blue
- Episode 103: Woody Harrelson, Todd Barry, Grafitti6
- Episode 104: Will Ferrell, Rufus Wainwright
- Episode 105: Zach Galifianakis, Former U.S. Army Sgt. Valerie Brown, Allen Stone
- Episode 106: Jonah Hill, Dr. Leonard Girardi, Milo Greene
- Episode 107: Joel McHale, Andrew Norelli, Will.I.Am
- Episode 108: Andy Samberg, Ashton Eaton, Glen Hansard
- Episode 109: Jennifer Garner, The U.S. Women's Olympic Gymnastics team, Rodriguez
- Episode 110: Tom Brokaw, Dana Vollmer, Beth Orton
- Episode 111: Tracy Morgan, Erik Kynard, Ben Howard
- Episode 112: Kelsey Grammer, Olivia Munn, Train
- Episode 113: Bill Hader, Mary-Louise Parker, The Walkmen
- Episode 114: Rachel Maddow, Serena Williams, Elle King
- Episode 115: Kathy Griffin, Michael Somerville, Josh Turner
- Episode 116: Jake Gyllenhaal, Sharon Osbourne, Neon Trees
- Episode 117: Amy Adams, Paul Teutul Sr. & Paul Teutul Jr., Hacienda
- Episode 118: Michelle Obama, The Chevin
- Episode 119: Bruce Willis, Brian Regan, The Heavy
- Episode 120: Claire Danes, Dwyane Wade, Bob Mould
- Episode 121: Emma Watson, Julie Chen, Matchbox Twenty
- Episode 122: Howard Stern, Jason Aldean
- Episode 123: Joseph Gordon Levitt, Mindy Kaling, Of Gentlemen and Cowards
- Episode 124: President Barack Obama
- Episode 125: Michael Strahan, Arthur Meyer
- Episode 126: Nathan Lane, Ryan Hunter-Reay, The Killers
- Episode 127: Steve Martin, Gotye
- Episode 128: Stupid Human Tricks, Kaley Cuoco, The Whigs
- Episode 129: David Cameron, Jonny Lee Miller
- Episode 130: Jimmy Fallon, Neil Young, Lupe Fiasco
- Episode 131: Regis Philbin, Tom Dreesen, Dwight Yoakam
- Episode 132: Stephen Colbert, Theresa Caputo, Martha Wash
- Episode 133: Martin Short, Kat Dennings
- Episode 134: Tina Fey, Rick Santorum, LP
- Episode 135: Craig Ferguson, Anna Kendrick, The Raveonettes
- Episode 136: Billy Crystal, The Wallflowers
- Episode 137: Jack Hanna, Max Greenfield
- Episode 138: Kevin James, Chris Elliott, Miguel
- Episode 139: Salma Hayek Pinault, Nick Offerman, KISS
- Episode 140: Lucy Liu; Rob Corddry; Daughter
- Episode 141: John Goodman, Jeff Altman, Jamey Johnson with Alison Krauss
- Episode 142: Tom Hanks; Tony Bennett
- Episode 143: Taylor Swift; Rachel Maddow
- Episode 144: Bill O'Reilly; Nicole Snooki Polizzi; The Lumineers
- Episode 145: Donald Trump; Adam Levine; Carly Rae Jepsen
- Episode 146: Dennis Quaid; Krysten Ritter; Diamond Rings
- Episode 147: Denzel Washington, Paul Banks
- Episode 148: Jim Cantore; Ken Burns; Andrew Bird
- Episode 149: Katie Couric; Rita Ora
- Episode 150: Steven Tyler and Joe Perry; Judy Greer; Aerosmith
- Episode 151: Jason Sudeikis; Michael Che; Ultraĩsta
- Episode 152: Ricky Gervais; Simon Helberg; Ty Segall
- Episode 153: Brian Williams; Ne-Yo
- Episode 154: Robin Williams; Lianne La Havas
- Episode 155: Anderson Cooper; Myq Kaplan; Alberta Cross
- Episode 156: Bradley Cooper; Robert Klein; Soundgarden
- Episode 157: Julianna Margulies; Mumford & Sons
- Episode 158: Alec Baldwin; Dirty Projectors
- Episode 159: Zooey Deschanel; Lisa Lampanelli; Donald Fagen
- Episode 160: Dr. Phil McGraw; Carmen Lynch; Divine Fits
- Episode 161: Jessica Biel; Pete Townshend; Philip Phillips
- Episode 162: Amy Poehler; Josh Hutcherson; Tegan and Sara
- Episode 163: Scarlett Johansson; Willie Nelson; Gary Clark Jr.
- Episode 164: Led Zeppelin; John Krasinski; Paloma Faith
- Episode 165: Matt Damon; Martin Freeman; JD McPherson
- Episode 166: Albert Brooks; Diana Krall
- Episode 167: Bill Murray; Vintage Trouble
- Episode 168: Dustin Hoffman; One Direction
- Episode 169: Anne Hathaway; Jake Johnson; “The President's Own” United States Marine Band
- Episode 170: Amanda Seyfried; Natalia Makarova; Awolnation
- Episode 171: Billy Crystal; James Balong; Grizzly Bear
- Episode 172: Jamie Foxx; Julie Chen; DIIV
- Episode 173: Samuel L. Jackson; Carrie Brownstein & Fred Armisen; Jason Isbell and the 400 Unit
- Episode 174: Tom Cruise; MNDR
- Episode 175: Paul Rudd; Alicia Keys
- Episode 176: Seth Rogen; John Witherspoon
- Episode 177: Katie Holmes; Jon Bon Jovi
- Episode 178: Naomi Watts; Jay Thomas; Darlene Love
Late Show with David Letterman - Season 19 Episode 148 : Jim Cantore; Ken Burns; Andrew Bird
Meteorologist Jim Cantore; documentary filmmaker Ken Burns; musical guests St. Vincent and David Byrne (Kate Hudson, from "Glee" Scheduled, cancelled to due to Hurricane Sandy)
