Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Luke Wilson, Julie Chen, Lee Brice
- Episode 2: Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers
- Episode 3: Steve Buscemi, Indy Car Season Champ, Alt-J
- Episode 4: Tina Fey, Moody McCarthy, Kevin Drew
- Episode 5: Bill Maher, Henrik Lundqvist, Spoon
- Episode 6: Michael Strahan, Richard Branson, Interpol
- Episode 7: Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson
- Episode 8: Jason Bateman, Billy Eichner, Ryan Adams
- Episode 9: Mindy Kaling, Jake Johannsen, Maddie & Tae
- Episode 10: Mark Harmon, "Jungle" Jack Hanna
- Episode 11: Denzel Washington, Lenny Kravitz
- Episode 12: Kelly Ripa, Jim Gaffigan, Paloma Faith
- Episode 13: Jerry Seinfeld, Michael Jackson ONE
- Episode 14: Ted Danson, Andrew Norelli
- Episode 15: Neil Patrick Harris, Jamie Oliver, Aretha Franklin
- Episode 16: John Oliver, Maggie Q, Bleachers
- Episode 17: Bill O'Reilly, Cristin Milioti
- Episode 18: Johnny Galecki, Andre Benjamin, Delta Spirit
- Episode 19: Mariska Hargitay, Simon Amstell, Kandace Springs
- Episode 20: Aziz Ansari, Tom Dreesen
- Episode 21: Robert Downey Jr., Sarah Paulson, Lizzo
- Episode 22: Anderson Cooper, Gina Rodriguez, Hatsune Miku
- Episode 23: Robert Duvall, Elle Fanning, Rival Sons
- Episode 24: Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley
- Episode 25: Russell Brand, Dave Grohl, Foo Fighters
- Episode 26: Michael Keaton, Foo Fighters
- Episode 27: Bill Murray, Foo Fighters
- Episode 28: Tom Selleck, Jenny Slate, Foo Fighters
- Episode 29: Jessica Chastain, Lenny Marcus, Foo Fighters
- Episode 30: Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis
- Episode 31: Taylor Swift, Tom Mison
- Episode 32: Jim Carrey, David Tennant
- Episode 33: Brian Williams, Perfume Genius
- Episode 34: Keith Olbermann, Brian Regan, Run the Jewels
- Episode 35: Martin Short, Father John Misty
- Episode 36: Jennifer Lopez, Rob Riggle, Kimbra
- Episode 37: Whoopi Goldberg, Jimmy Page, Mapei
- Episode 38: Amy Schumer, Jeff Caldwell
- Episode 39: Katie Holmes, Alex Zanardi
- Episode 40: Steve Carell, Martha Stewart, OK Go
- Episode 41: Jennifer Lawrence, Boris Johnson
- Episode 42: Jon Stewart, Shawn Mendes
- Episode 43: Kristin Chenoweth; Chris Young
- Episode 44: Jason Sudeikis, Allison Janney, Damien Rice
- Episode 45: Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger
- Episode 46: Regis Philbin, Hundred Waters
- Episode 47: Edward Norton, Jessye Norman
- Episode 48: Norman Lear, TV on the Radio
- Episode 49: Seth Rogen, Amy Sedaris
- Episode 50: Emily Blunt, Adam Resnick, Wu-Tang Clan
- Episode 51: Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz
- Episode 52: Joaquin Phoenix, Cristela Alonzo, Al Green
- Episode 53: Ben Stiller, Olivia Munn, LaLa Brooks
- Episode 54: Meryl Streep, Rebel Wilson, J. Cole
- Episode 55: Chris Rock, Sting
- Episode 56: Jamie Foxx, Robert Klein, Dan Penn
- Episode 57: Emma Stone Top, Marcus Mariota, Bob Seger
- Episode 58: New Holiday Toys, Anna Kendrick, Charli XCX
- Episode 59: Tom Brokaw, Will Nelson & Billy Joe Shaver
- Episode 60: Rosie O’Donnel,l Jeff Altman
- Episode 61: Jay Thomas, Josh Brolin, Darlene Love
- Episode 62: Kathy Griffin, David Oyelowo, Lera Lynn
- Episode 63: Ethan Hawke, Allison Williams, Parquet Courts
- Episode 64: Julianne Moore, Catfish & the Bottlemen
- Episode 65: Donald Trump, Chelsea Peretti, Foxygen
- Episode 66: Michael Somerville, Nicole Atkins
- Episode 67: Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones
- Episode 68: Anderson Cooper, Shovels & Rope
- Episode 69: Amanda Peet, Ryn Weaver
- Episode 70: Larry David, Dan Patrick, Sleater-Kinney
- Episode 71: Urban Meyer, Johnny Beehner, Ella Henderson
- Episode 72: Louis CK, Nicolle Wallace, the Lone Bellow
- Episode 73: Andrew Luck, Oscar Isaac, Drenge
- Episode 74: Viola Davis, Ben Schwartz, Marty Stuart
- Episode 75: John Oliver, Mayim Bialik, Death Cab for Cutie
- Episode 76: Aziz Ansari, Brian Kiley, Ben Howard
- Episode 77: Jack Hanna, Sharon Jones and the Dap-Kings
- Episode 78: Dr. Phil McGraw, Robin Tunney, Diana Krall
- Episode 79: Ryan Reynolds, Dierks Bentley
- Episode 80: Martin Short, Bettye Lavette
- Episode 81: Sienna Miller, Andy Kindler, Bob Mould
- Episode 82: Steve Carell, Dr. Cornel West
- Episode 83: Courtney Love, Chris Elliott, Rhiannon Giddens
- Episode 84: Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear
- Episode 85: Tom Hanks, Sturgill Simpson
- Episode 86: Bill Hader, Pat McGann, Shakey Graves
- Episode 87: Matthew Perry, Adam Scott, Kishi Bashi
- Episode 88: Dakota Johnson, David Tochinskiy, Twin Shadow
- Episode 89: Will Smith, Grizfolk
- Episode 90: Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko
- Episode 91: Kid Scientists, Sean Hayes, Judah & the Lion
- Episode 92: Helen Mirren, the 2015 Daytona 500 winner, Steve Earle
- Episode 93: Matthew Broderick, Ellie Kemper, JD McPherson
- Episode 94: Julianna Margulies, Eric Ripert, Glass Animals
- Episode 95: Kevin Spacey, Lily James, Alabama Shakes
- Episode 96: Patricia Arquette, Will Butler
- Episode 97: Kelsey Grammer, Stevie Wonder
- Episode 98: Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew
- Episode 99: Kevin Bacon, Jimmie Walker, Airborne Toxic Event
- Episode 100: Shailene Woodley, Dr. Cornel West, Matthew E. White
- Episode 101: Will Ferrell, Glen Hansard
- Episode 102: Norm MacDonald, Theo James
- Episode 103: Ben Stiller, Tove Lo
- Episode 104: Bill O'Reilly, Aubrey Plaza
- Episode 105: James Franco, Jake Johannsen, Action Bronson
- Episode 106: Neil Patrick Harris, Charlie Cox, the Suffers
- Episode 107: David Duchovny, Josh Gad, Houndmouth
- Episode 108: Sen. Al Franken, Billy Eichner, David Sanborn
- Episode 109: Kelly Ripa, Aasif Mandvi, Fat White Family
- Episode 110: Mike Myers, Nick Griffin, Banks
- Episode 111: Sarah Jessica Parker, Julie Chen, Asleep at the Wheel
- Episode 112: Billy Crystal, Chris Russo, Chris Stapleton
- Episode 113: Michael J. Fox, Iron & Wine, Ben Bridwell
- Episode 114: Kevin James, Tom Dreesen, Tracy Chapman
- Episode 115: Alec Baldwin, John Mayer
- Episode 116: John Travolta, Amy Schumer, the Waterboys
- Episode 117: Piedmont Bird Callers, Paul Rudd
- Episode 118: Bruce Willis, Dawes
- Episode 119: Robert Downey Jr., Chris Russo, Elvis Costello
- Episode 120: Jerry Seinfeld, Jason Isbell & Amanda Shires
- Episode 121: Scarlett Johansson, John Mellencamp, Todd Rundgren
- Episode 122: Michael Keaton, Future Islands
- Episode 123: Jack Hanna, John Popper
- Episode 124: First Lady Michelle Obama Hootie and the Blowfish
- Episode 125: Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor
- Episode 126: President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile
- Episode 127: Reese Witherspoon, Nathan Lane, Mumford & Sons
- Episode 128: Martin Short, Norah Jones
- Episode 129: Tina Fey, First Aid Kit
- Episode 130: Ray Romano, Brian Regan, Dave Matthews Band
- Episode 131: Howard Stern, Don Rickles
- Episode 132: Bill Clinton, Adam Sandler
- Episode 133: Julia Roberts, Paul Shaffer, Ryan Adams
- Episode 134: Al Pacino, George Clooney, Tom Waits
- Episode 135: Oprah Winfrey, Norm Macdonald
- Episode 136: Tom Hanks, Eddie Vedder
- Episode 137: Bill Murray, Bob Dylan
- Episode 138: The Final Late Show with David Letterman
- Episode 149: Episode 149
Late Show with David Letterman - Season 22 Episode 149 : Episode 149
The final episode includes surprises, memorable highlights and the last Top Ten List.
