Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Terry Bradshaw, Carmen Electra, Eddie Brill
- Episode 2: Steven Seagal, Brittany Starr, Beck
- Episode 3: Joan Lunden, Chris Rock, Fiona Apple
- Episode 4: Geena Davis, Martha Stewart, Robert Carlyle
- Episode 5: Kevin Kline, Jamie Foxx, Sugar Ray
- Episode 6: Danny DeVito, Patrick Rafter, Tim McGraw
- Episode 7: Salma Hayek, Joan Cusak, Louie Anderson
- Episode 8: Noah Wylie, Damon Wayons, Missy "Misdemeanor" Elliot
- Episode 9: Andie MacDowell, Cynthia Cooper, Nanci Griffith & Darius Rucker
- Episode 10: Jennifer Jason Leigh, Starr Jones, Bee Gees
- Episode 11: George Clooney, Bill Cosby
- Episode 12: Nicole Kidman, Gregory Hines, God's Property
- Episode 13: Jennifer Lopez, Michael Lamonico, Bill Engvall
- Episode 14: Alec Baldwin, Jonathan Lipnicki, Deana Carter
- Episode 15: Kim Basinger, Ray Ramano, Jackson Browne
- Episode 16: Fourth Anniversary Special
- Episode 17: Fran Drescher, Ryan Tripp, Brooks & Dunn
- Episode 18: Michael J. Fox, Sarah O'Hare, Patti Smith
- Episode 19: Cameron Diaz, Adam Arkin, Veniamin
- Episode 20: Matt Lauer, Ryan Kurlander, Sheryl Crow
- Episode 21: Elle MacPherson, Jon Tenney, Elvis Costello & the Fairfield Four
- Episode 22: Dan Aykroyd, Jack Hanna, Boyz II Men
- Episode 23: Bryant Gumbel, Harland Williams, Everclear
- Episode 24: John Lithgow, Christy Turlington, Foo Fighters
- Episode 25: James Belushi, Christina Ricci, Oasis
- Episode 26: Uma Thurman, Mark Wahlberg, Eddie Izzard
- Episode 27: David Duchovny, Emily Mae Young, Todd Barry
- Episode 28: Tom Brokaw, Stevie Starr, Green Day
- Episode 29: Nathan Lane, Chalize Theron, Carly Simon
- Episode 30: Mike Wallace, Kelly Montieth, LL Cool J
- Episode 31: Robert Pastorelli, Harmony Korine, Smash Mouth
- Episode 32: Mariah Carey, Anthony Clark
- Episode 33: Maria Martiromo, Penn & Teller, Amy Grant
- Episode 34: Ellen Barkin, Bobby Bonilla, Angelo Massagli
- Episode 35: Kid Scientists, David Hyde Pierce, Andy Greene
- Episode 36: Stupid Human Tricks, Naomi Campbell, Bobby Brown
- Episode 37: John Travolta, Cybill Shepard, Kuznetsov Troupe
- Episode 38: Danny Aiello, Helena Bonham Carter, Mandy & Dora Lee Patinkin
- Episode 39: Sarah Ferguson, Kelly McGillis, Leann Rimes
- Episode 40: Harry Connick Jr., Pamela Lee
- Episode 41: Robert F. Kennedy Jr., Heather Matarazzo, B.B. King & Tracy Chapman
- Episode 42: Wesley Snipes, Naomi Judd, Martina Hingis
- Episode 43: Claire Danes, Michelle Kwan, Lorrie Morgan
- Episode 44: Marv Albert, Daniel Scribner & Tylin Hall, John Fogerty
- Episode 45: Bill Murray, Alison Eastwood, Matchbox 20
- Episode 46: Don Rickles, Heather Graham, Lou Reed
- Episode 47: Richard Simmons, Venus Williams, Wynonna
- Episode 48: Tom Arnold, Kordell Stewart, Elvis Costello
- Episode 49: Sigourney Weaver, David Brenner, Trischa Yearwood
- Episode 50: Danny DeVito, Sarah Michelle Gellar
- Episode 51: Kirstie Alley, Luke Perry, Shengyang Acrobats
- Episode 52: John Cusak, Natalie Portman, Stomp with Bill Irwin
- Episode 53: Kids Tell Jokes, Marisa Tomei, James Taylor
- Episode 54: Stupid Pet Tricks, Anthony Edwards, Joost Elffers
- Episode 55: Kevin Spacey, Art Donovan, Wallflowers
- Episode 56: Jon Stewart, John Witherspoon, Days of the New
- Episode 57: Courteney Cox, Peyton Manning, Shania Twain
- Episode 58: Helen Hunt, Terrell Davis, Chumbawamba
- Episode 59: Sir Anthony Hopkins, Eric Lindros, Enya
- Episode 60: Nathan Lane, Hazelle Goodman, Mitch Fatel
- Episode 61: Alex D Linz, Jerry O'Connell, Bryan Adams
- Episode 62: Kevin Costner, Tyra Banks, Nina & Nickolai
- Episode 63: Pam Grier, Tom Everett Scott, James Brown
- Episode 64: Greg Kinnear, Djimon Hounsou, Ben Folds Five
- Episode 65: Leslie Nelson, Michelle Yeoh, Hanson
- Episode 66: Pierce Brosnan, Lou Holtz
- Episode 67: Joan Lunden, Angelo Massaglini, G. Love with Special Sauce & Dr. John
- Episode 68: Terry Bradshaw, Billy Zane, Darlene Love
- Episode 69: Quentin Tarantino, Anne Heche, Kenny Wayne Shepard Band
- Episode 70: Bridget Fonda, Matt Damon, Allan Harvey
- Episode 71: Marilu Henner, Leila Kenzle, George Miller
- Episode 72: Samuel L. Jackson, Howie Long, Louie C.K.
- Episode 73: Tom Brokaw, Tobey Maquire, Fiona Apple
- Episode 74: Norm MacDonald, Peta Wilson, Streb
- Episode 75: Minnie Driver, Paul Simon, Cast of The Capeman
- Episode 76: Penelope Ann Miller, Terry Pledger, Collective Soul
- Episode 77: Robin Williams, Dave Chappelle, Stevie Nicks and Lindsey Buckingham
- Episode 78: Bill Pullman, Jim Breuer, Stevie Nicks and Lindsey Buckingham
- Episode 79: Peter O'Toole, Martin Scorcese
- Episode 80: Kenneth Branagh, Spice Girls, Jim Nantz
- Episode 81: Ben Stiller, Sandra Bernhard, Jars of Clay
- Episode 82: Michael Isikoff, Sarah Ferguson
- Episode 83: Robert Duvall, Kennedy, Emmylou Harris
- Episode 84: Michael Keaton, Brian Williams, Blues Traveller
- Episode 85: David Spade, Justin Miller, Jeff Garlin
- Episode 86: Ethan Hawke, Merrill Markoe
- Episode 87: Tom Arnold, Steve Forbes, Jake Johannsen
- Episode 88: John Goodman, Mitch Hedberg, Jeff Gordon
- Episode 89: Dan Akroyd, Naomi Campbell, Duncan Sheik
- Episode 90: Dan Rather, Honeymoon the pig, Cast of Ragtime
- Episode 91: Drew Barrymore, Shania Twain
- Episode 92: Richard Simmons, John Elway
- Episode 93: Bill Cosby, Blues Brothers
- Episode 94: Stupid Human Tricks, Cindy Crawford, Jonny Moseley
- Episode 95: Adam Sandler, Jack Hanna
- Episode 96: Bruce Willis, LeAnn Rimes & Bryan White
- Episode 97: Heather Locklear, Tom Selleck
- Episode 98: Mike Myers, Paula Cole
- Episode 99: Nathan Lane, Bingo Granny
- Episode 100: Bob Dole, Marilyn Manson
- Episode 101: Stupid Pet Tricks, Jonny Moseley
- Episode 102: Jeff Bridges, Nikki Stone, John Fogerty
- Episode 103: Kelsey Grammer, Sarah Tueting & Cammi Granato, Sarah McLachlan
- Episode 104: Susan Sarandon, Eric Bergoust, Aretha Franklin
- Episode 105: David Schwimmer, Chris Witty, Shawn Colvin
- Episode 106: Kate Winslet, Tara Lipinski, Ray Romano
- Episode 107: Patrick Stewart, Frank Urbancic, Joan Cusak
- Episode 108: Kid Scientists, Gabriel Byrne, Richie Sambora
- Episode 109: Helena Bonham Carter, Peter Fonda, Loreena McKennitt
- Episode 110: Siskel & Ebert, Karl Malone, Mark Chesnutt
- Episode 111: Norm MacDonald, Richie Stachowski
- Episode 112: Emma Thompson, Alex Zanardi, Willie Nelson & Emmylou Harris
- Episode 113: John Travolta, Jack Johnson, The Chieftains
- Episode 114: Bill Murray, Eddie Izzard, Gheorge Meuresun
- Episode 115: Dennis Hopper, Robert Klein, Patricia Heaton
- Episode 116: Charles Grodin, Edward Burns, Marcy Playground
- Episode 117: Dolly Parton, Bob Hoskins
- Episode 118: Al Franken, Lauren Holly, Ani DiFranco
- Episode 119: Evander Holyfield, Joseph Loveland, Michael Moore
- Episode 120: Don Rickles, Mimi Rogers, Steve Miller
- Episode 121: Alec Baldwin, Heather Graham, Barenaked Ladies
- Episode 122: Tom Brokaw, Ice Cube, Natalie Imbruglia
- Episode 123: Tom Hanks, Matt Medenweldt, Scott Weiland
- Episode 124: Matt LeBlanc, Natasha Henstridge, The Lynns
- Episode 125: Quentin Tarantino, Steven Weber, Clint Black
- Episode 126: James Belushi, Lacey Chabert, Robbie Robertson
- Episode 127: Val Kilmer, Jimmie Walker, cast of Cabaret
- Episode 128: Billy Crystal, Hatty Jones, Tori Amos
- Episode 129: Gwyneth Paltrow, Harmony Korine, Wyclef Jean
- Episode 130: Claire Danes, George Miller, Matthew Ryan
- Episode 131: Jason Alexander, Isabella Rossellini, Steve Earle
- Episode 132: Ricki Lake, Vaughn Cordle, Rita Wilson
- Episode 133: Jennifer Aniston, Jerry Springer, Al Green
- Episode 134: Marisa Tomei, Ryan Leaf, Alana Davis
- Episode 135: Jack Hanna, Ray Allen, Dave Matthews Band
- Episode 136: Patrick Swayze, Hugh Hefner
- Episode 137: Gena Lee Nolan, Mark Wahlberg, Brian Regan
- Episode 138: Stupid Human Tricks, Norm MacDonald, Pearl Jam
- Episode 139: Elle MacPherson, Jon Favreau, Usher
- Episode 140: Donald Trump, Jayson Williams, Cast of Home Coming, Trisha Yearwood
- Episode 141: Sally Field, Philip Bigler, Lyle Lovett
- Episode 142: Matt Lauer, Jada Pinkett Smith, Green Day
- Episode 143: Marilu Henner, Jim Lovell
- Episode 144: Fran Drescher, Bob Berman, Faith Hill
- Episode 145: Christopher Reeve, Hanson
- Episode 146: Warren Beatty, Wayne Knight, Bonnie Raitt
- Episode 147: Jim Breuer, Tara Lipinski, Foo Fighters
- Episode 148: Richard Simmons, Beau Jaques and the Zydeco Highrollers
- Episode 149: Matthew Broderick, David Wells, Natalie Merchant
- Episode 150: Sandra Bullock, Jeff Foxworthy, Cast of One Small Step
- Episode 151: Drew Carey, Scarlett Johannson, Soul Asylum
- Episode 152: Ted Danson, Mae Whitman, The Flatlanders
- Episode 153: Harry Connick, Jr., Hank Azaria
- Episode 154: John Goodman, Esther Canadas, Sarah McLachlan
- Episode 155: Norm MacDonald, Jacques Villeneuve, Randy Travis
- Episode 156: Sarah Jessica Parker, Bill Bradley, Chase Butrell
- Episode 157: Evander Holyfield, Laura Linney, Fastball
- Episode 158: George Carlin, Bob Saget, Emmylou Harris, Indigo Girls, Luscious Jackson, Rebekah
- Episode 159: Whoopi Goldberg, Janeane Garofalo
- Episode 160: Bill Cosby, Andy Dick
- Episode 161: Bob Newhart, Nicole Sullivan, Wendy Liebman
- Episode 162: Harrison Ford, Dane Cook
- Episode 163: Charles Grodin, Paul Rodriguez
- Episode 164: Naomi Campbell, Luke Buchheit, Sinead O'Connor
- Episode 165: David Duchovny, Stevie Nicks
- Episode 166: Ellen Barkin, Jeff Altman, Sonic Youth
- Episode 167: Sam Donaldson, Gloria Reuben, Babyface & Des'ree
- Episode 168: Anthony Edwards, George Miller, Sean Lennon
- Episode 169: Piedmont Bird Callers, George Clooney, Steve Yzerman
- Episode 170: John McEnroe, The Pretenders
- Episode 171: Jennifer Lopez, Chris Eigeman, Largo
- Episode 172: Dennis Quaid, Chloe Sevigny, Grant Lee Buffalo
- Episode 173: Mary Tyler Moore, Ron Eldard
- Episode 174: Lisa Kudrow, Mike Piazza, Billy Bragg & Wilco
- Episode 175: Martha Anne Godwin, Kristen Johnston, Lucinda Williams
- Episode 176: Tom Brokaw, Steve Zahn, The Hummingbirds with Stevie Wonder & Paul Simon
- Episode 177: Ben Stiller, Hatty Jones, Spice Girls
- Episode 178: The Beltway Bunch, Stupid Pet Tricks, Bob Dole
- Episode 179: Don Rickles, Matt Drudge, Cherry Poppin' Daddies
- Episode 180: Matt Dillon, Daniel Boulud, Arj Barker
- Episode 181: Antonio Banderas, Chris Elliot
- Episode 182: Anthony Hopkins, Cowboy Junkies
- Episode 183: Gabriel Byrne, John Witherspoon, Tricky & P.J. Harvey
- Episode 184: James Caan, Buck O'Neil, Lenny Kravitz
- Episode 185: Janet Jackson, Scott Farrell, Nanci Griffith
- Episode 186: Tony Danza, Peter Farrelly, Brian Wilson
- Episode 187: Marilu Henner, Gloria Estefan
- Episode 188: Pauly Shore, Pam Grier, Natalie Imbruglia
- Episode 189: Jenny McCarthy, Adam Arkin, Tori Amos
- Episode 190: Kids with animals, Gary Sinise, Goo Goo Dolls
- Episode 191: Yasmine Bleeth, David Brenner, Barenaked Ladies
- Episode 192: Samuel L. Jackson, Jenni, Smashing Pumpkins
- Episode 193: Jamie Lee Curtis, George Freestone
- Episode 194: Drew Barrymore, Dee Dee Meyers, The Verve
- Episode 195: Noyz Boyz, Nathan Lane, Boy George & Culture Club
- Episode 196: Penn & Teller, French Stewart, Wynton Marsalis
- Episode 197: Jerry Seinfeld, Hunter Scott
- Episode 198: Tom Arnold, Doris Roberts, Blues Traveler
- Episode 199: Leslie Nielsen, David Roth, Teresa Witherspoon
- Episode 200: Kevin Spacey, Bobby Rahal, Harvey Danger
- Episode 201: Ray Liotta, Sela Ward, Liz Phair
- Episode 202: Angela Basset, Pete Townshend
- Episode 203: Wesley Snipes, Robert Klein
Late Show with David Letterman - Season 5 Episode 141 : Sally Field, Philip Bigler, Lyle Lovett
Biff tries out tobacco juice spin art; Dave shows a clip from last night's show in which he mixed up ""Viagra"" with ""Niagara""; Biff teaches Sally Field how to spit tobacco juice.
