Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Jean-Claude Van Damme, Darryl Strawberry, Joe Cocker
- Episode 2: Beau Bridges, Terrell Davis, Squirrel Nut Zippers
- Episode 3: Terry Bradshaw, Jesse Jackson
- Episode 4: Ray Romano, Chris Cardone, Tom Agna
- Episode 5: Stupid Human Tricks, Jason Patric, Eve 6
- Episode 6: Richard Simmons, Luisa Conlon
- Episode 7: Andie MacDowell, Willie Nelson
- Episode 8: Tim Forneris, Stephen Dorff, Wynonna
- Episode 9: Charles Grodin, Paul Hopkins
- Episode 10: Jack Hanna, Gretchen Mol, Nick Cave & The Bad Seeds
- Episode 11: Cindy Crawford, Jeff Greenfield, Hootie & The Blowfish
- Episode 12: Ben Stiller, Jackie Chan, Vince Gill
- Episode 13: Bill Cosby, George Hamilton
- Episode 14: Denis Leary, George Hamilton
- Episode 15: Vince Vaughn, Brian Benben, Brian Setzer Orchestra
- Episode 16: Michael J. Fox, Evander Holyfield, Dixie Chicks
- Episode 17: Jennifer Lopez, Meredith Viera, Lyle Lovett
- Episode 18: Stupid Pet Tricks, Marv Albert, Kevin James
- Episode 19: Howard Stern, Katie Holmes
- Episode 20: Jon Stewart, Jean Reno, Rob Zombie
- Episode 21: Fran Drescher, Chris Kattan, Elvis Costello & Burt Bacharach
- Episode 22: Chris Tucker, Faith Ford, Eagle Eye Cherry
- Episode 23: Kelsey Grammer, Nick Mason, Tony Bennett
- Episode 24: Drew Carey, Billy Connolly, Hedwig & The Angry Inch
- Episode 25: Steve Martin, Cokie Roberts
- Episode 26: Kelly Preston, Peter Boyle, Semisonic
- Episode 27: Elizabeth & Bob Dole, Joaquin Phoenix
- Episode 28: Jeff Goldblum, John Mellencamp
- Episode 29: Isabella Rossellini, Stephen Baldwin, George Miller
- Episode 30: Joan Lunden, Jeff Altman, Sheryl Crow
- Episode 31: Mark McGwire, Robert Benigni, Bruce Hornsby
- Episode 32: State Fair Champions, Ringo Starr
- Episode 33: Jeff Daniels, David Cross, Mitch Hedberg
- Episode 34: Danny Glover, Cal Ripken Jr., R.E.M.
- Episode 35: Naomi Campbell, David Wells, R.E.M.
- Episode 36: Danny DeVito, Joe Torre, Eddie Brill
- Episode 37: Martin Short, Eddie Izzard, Phish
- Episode 38: Daniel Baldwin, Todd Solondz, Phil Collins
- Episode 39: Holly Hunter, Hunter S. Thompson, Garbage
- Episode 40: Ted Danson, Denny Brauer, Black Sabbath
- Episode 41: Anthony Hopkins, Buzz Aldrin, Depeche Mode
- Episode 42: Queen Latifah, Ellie Lammer, Darrell Hammond
- Episode 43: Adam Sandler, Jayson Williams, Soul Coughing
- Episode 44: Denzel Washington, Father Mike Berner
- Episode 45: George Pataki, Evan Metropoulis, P.J. Harvey
- Episode 46: George Michael, Col. Gail Halverson, Hanson
- Episode 47: Luke Perry, Tom Wolfe, Jay-Z
- Episode 48: Melanie Griffith, Walter Cronkite, Travis Tritt
- Episode 49: Roma Downey, Kenneth Branagh, Goo Goo Dolls
- Episode 50: Donald Trump, Doug Flutie, Sarah Silverman
- Episode 51: Kid Scientists, Cameron Diaz, Mariah Carey
- Episode 52: Will Smith, Jack Hanna
- Episode 53: Cher, Jerry Springer
- Episode 54: Christian Slater, Celine Dion & Bryan Adams
- Episode 55: Drew Barrymore, Siskel & Ebert
- Episode 56: Helen Hunt, Ray Romano
- Episode 57: Geena Davis, Martha Stewart, Roger Daltry
- Episode 58: Gwyneth Paltrow, Peter Berg, Bonnie Raitt
- Episode 59: Michael Caine, Art Donavon, Jewel
- Episode 60: Salma Hayek, Marilyn Manson, Caroline Rhea
- Episode 61: Patrick Stewart, Jon Stewart, Faith Hill
- Episode 62: Greg Kinnear, Jane Horrocks, Reggie McFadden
- Episode 63: Tom Hanks, Brooklyn Philharmonic
- Episode 64: Meg Ryan, Whitney Houston
- Episode 65: Tom Brokaw, Famke Janssen, Emmylou Harris
- Episode 66: Robin Williams, Natalie Merchant
- Episode 67: Val Kilmer, Ricky Williams, Billy Bragg & Natalie Merchant
- Episode 68: Susan Sarandon, Marc Weinberg, Vienna Choir Boys
- Episode 69: Jeff Goldblum, Angelina Jolie, Third Eye Blind
- Episode 70: Julia Roberts, David Kelly
- Episode 71: Barbara Walters, Josh Hartnett, Cyndi Lauper
- Episode 72: Charles Grodin, John Witherspoon, Jessye Norman
- Episode 73: John Travolta, Darlene Love
- Episode 74: Chazz Palminteri, Ann Curry, Rufus Wainwright
- Episode 75: James Woods, David Brenner, Cast of But Boy Could He Sing
- Episode 76: Jay Thomas, Vinny Testaverde, Patti Smith
- Episode 77: Stupid Human Tricks, Nathan Lane, St. Luke's Bottle Band
- Episode 78: Jon Voight, Jena Malone, Louie C.K.
- Episode 79: Sarah Jessica Parker, David Remnick, Bryan Callan
- Episode 80: Jennifer Jason Leigh, Liam Aiken, Greg Behrendt
- Episode 81: Mira Sorvino, Terry Bradshaw
- Episode 82: Lisa Kudrow, Terry Bradshaw, Jason Kuller
- Episode 83: Jon Stewart, Marv Albert, Jim Gaffigan
- Episode 84: Gillian Anderson, Charlie Rose, Black Crowes
- Episode 85: Robert Duvall, Al Franken, B.B. King
- Episode 86: Conan O'Brian, Alanis Morrisette
- Episode 87: William Baldwin, Trisha Yearwood, Scott Ferrall
- Episode 88: Jack Hanna, Patricia Arquette
- Episode 89: Yasmine Bleeth, Adam Carolla, James Brown
- Episode 90: Alicia Silverstone, D.L. Hughley, Second Hand
- Episode 91: Sophia Loren, The Mavericks
- Episode 92: Bill Murray, Shania Twain
- Episode 93: Cate Blanchett, Jason Schwartzman, Brandy
- Episode 94: Bill Cosby, Brendon Fraser, Ricky Scruggs & Vince Gill
- Episode 95: Tom Arnold, David Brenner, Catherine Bell
- Episode 96: Tom Brokaw, Sean Patrick Flanery, Creed
- Episode 97: Mel Gibson, Laetitia Casta, Fresh Step
- Episode 98: Stupid Pet Tricks, Martha Stewart, Mitch Hedberg
- Episode 99: Michael J. Fox, Rev. John & Ellena Cobb, Willie Nelson
- Episode 100: Jeff Daniels, Fernanda Montenegro, Monica
- Episode 101: Robin Wright Penn, Richard Kind, Chris Isaak
- Episode 102: Sandra Bullock, James Carville, Hootie & The Blowfish
- Episode 103: Richard Simmons, Sarah O'Hare, Ondar
- Episode 104: Bette Midler, David Hyde Pierce
- Episode 105: Andy Garcia, Tara Lipinksi, Wendy Liebman
- Episode 106: Andie MacDowell, Mike Judge, Julian Lennon
- Episode 107: Magic Johnson, Jake Gyllenhaal, Jewel
- Episode 108: Lauren Bacall, Greg Smith, Sugar Ray
- Episode 109: Matthew Broderick, Sheryl Crow
- Episode 110: Kid Scientists, Jesse Ventura
- Episode 111: Uma Thurman, Tom Green, De La Guarda
- Episode 112: Eriq La Salle, Homer Hickman, Blondie
- Episode 113: James Coburn, Will Ferrall, Marvelous Three
- Episode 114: Brooke Shields, Peter Hillary
- Episode 115: Ian McKellen, Reese Witherspoon, The Roots & Erykah Badu
- Episode 116: Kid Turkey Callers, Mark Wahlberg, Fresh Step
- Episode 117: Billy Crystal, George Miller
- Episode 118: Chazz Palminteri, Jeff Altman, Everclear
- Episode 119: Norm MacDonald, Jeff Beck
- Episode 120: Elizabeth Hurley, Katie Holmes, Cake
- Episode 121: Stupid Human Tricks, Craig Kilborn, Emmylou Harris, Linda Rondstadt, and Dolly Parton
- Episode 122: Elton John, Henry Kissinger, LeAnn Rimes
- Episode 123: Ron Howard, Charlotte Church
- Episode 124: Marv Albert, Diane Lane, Blur
- Episode 125: Laurence Fishburne, Sister Carol Anne Corley, Wilco
- Episode 126: Steve Martin & Goldie Hawn, Jim Calhoun, Joe Henry
- Episode 127: Dennis Hopper, Jason Nastke, The Corrs
- Episode 128: Marilu Henner, Master P, Greg Fitzsimmons
- Episode 129: Charles Grodin, David Arquette, Willie Nelson, Lyle Lovett, and Kris Kristofferson
- Episode 130: Drew Barrymore, Scott Wolf, Barenaked Ladies
- Episode 131: Lennox Lewis, Dr. Bertrand Piccard & Brian Jones
- Episode 132: George Stephanopoulos, Molly Shannon, Andrea Bocelli
- Episode 133: Bill Maher, Khalid El-Amin, Marc Maron
- Episode 134: Elle Macpherson, Don Zimmer, John Mellencamp
- Episode 135: Kevin Spacey, Tom Petty & The Heartbreakers
- Episode 136: Kate Winslet, Darrell Hammond, Mandy Barnett
- Episode 137: David Spade, Tim Couch, Eagle-Eye Cherry
- Episode 138: John Cusack, Jack Hanna
- Episode 139: Matthew Broderick, Ben Stein, The Cranberries
- Episode 140: Martin Lawrence, Michelle Williams, Eddie Brill
- Episode 141: Dustin Hoffman, Mary Steenburgen, Ben Folds Five
- Episode 142: Ted Danson, Sarah Ferguson, Madness
- Episode 143: Glenn Close, George Hamilton, Elvis Crespo
- Episode 144: Tom Brokaw, Robbie Williams
- Episode 145: Earvin Magic Johnson, Sara Gentile, Silverchair
- Episode 146: Denny Brauer, Kelly Willis, Jesse Jackson
- Episode 147: Brendan Fraser, Jesse Jackson, Bonnie Raitt
- Episode 148: Kelsey Grammer, Steve Earle and the Del McCoury Band
- Episode 149: Stupid Pet Tricks, Janeane Garofalo, Brian Regan
- Episode 150: Ben Stiller, Camryn Manheim, Eve 6
- Episode 151: Kathie Lee Gifford, Deana Carter
- Episode 152: Kevin Kline, Leelee Sobieski, Beth Orton
- Episode 153: Bill Cosby, Jon Favreau
- Episode 154: Julia Roberts, Alice Cooper
- Episode 155: Keri Russell, Aretha Franklin
- Episode 156: Tom Selleck, Bob Barker, Leon Russell
- Episode 157: Helen Hunt, Courtney Love, Hole
- Episode 158: Natalie Portman, Tom Everett Scott, J. Geils Band
- Episode 159: Harry Connick Jr., Damon Wayans
- Episode 160: Kate Capshaw, Britney Spears
- Episode 161: Kid Scientists, Sarah Jessica Parker, Mary Chapin Carpenter
- Episode 162: Bill Murray, Everlast
- Episode 163: Jennifer Lopez, Ira Glass
- Episode 164: Dan Rather, Nancy Mace, Randy Newman
- Episode 165: Jeff Foxworthy, Kristin Davis, Snoop Dogg
- Episode 166: Timothy Hutton, Christine Lahti, Cast of It Ain't Nothing But the Blues
- Episode 167: Ray Romano, Jewel
- Episode 168: Heather Graham, David Wells
- Episode 169: Tim Robbins, Oscar De La Hoya, Dane Cook
- Episode 170: Roseanne, Susan Tedeschi
- Episode 171: David Schwimmer, Brandi Chastain, Seth Green
- Episode 172: Mike Myers, Ben Lee
- Episode 173: Julianna Margulies, Jon Stewart
- Episode 174: Felicity Huffman, Andy Dick, Elvis Costello
- Episode 175: Adam Sandler, Missy Elliot
- Episode 176: Geri Halliwell, Richard Belzer
- Episode 177: Rudolph Giuliani, Leslie Mann, The Pretenders
- Episode 178: Joey Lauren Adams, Spike Lee, Santana
- Episode 179: Colin Powell, Maurice Green
- Episode 180: Mira Sorvino, Lyle Lovett
- Episode 181: Piedmont Bird Callers, Avery Johnson, June Carter Cash
- Episode 182: Calista Flockhart, Jack Hannah
- Episode 183: Stupid Human Tricks, John Leguizamo, Ziggy Marley & The Melody Makers
- Episode 184: John McEnroe, George Jones
- Episode 185: Chris Rock, Sixpence None the Richer
- Episode 186: Lindsay Davenport, Oliver Platt, Jeffrey Ross
- Episode 187: Jay Thomas, Jason Briggs
- Episode 188: Naomi Campbell, Jimmie Walker, Lucinda Williams
- Episode 189: Don Rickles, Dave Mirra, Patty Griffin
- Episode 190: U.S. 1999 World Cup Women's Soccer Team, Jim Gaffigan
- Episode 191: Matthew Broderick, Dennis Regan
- Episode 192: Catherine Zeta-Jones, Buzz Aldrin, Jamiroquai
- Episode 193: Charles Grodin, Alanis Morrisette
- Episode 194: Ted Koppel, Isabella Rossellini, Macy Gray
- Episode 195: National Hollerin' Champions, Garry Marshall, Los Lobos
- Episode 196: Samuel L. Jackson, Rita Wilson, Pete Townshend & Eddie Vedder
- Episode 197: Bruce Willis, Heidi Klum
- Episode 198: Lance Armstrong, Barry White
- Episode 199: Pierce Brosnan, Saffron Burrows, Jim Jeter
- Episode 200: Tom Arnold, Q-Tip & Busta Rhymes
- Episode 201: Dave Foley, Jonathan Witherspoon, Old 97's
- Episode 202: William H. Macy, George Miller, The Pretenders
- Episode 203: Ray Romano, Jeff Altman
- Episode 204: Regis Philbin, Dave Attell
- Episode 205: Claire Danes, Smash Mouth
- Episode 206: Hugh Grant, The Mavericks
- Episode 207: Rene Russo, Tori Amos
- Episode 208: Shaquille O'Neal, Helen Mirren
- Episode 209: Tony Danza, Katie Holmes, Robert Palmer
- Episode 210: Lara Flynn Boyle, David Brenner, Everclear
- Episode 211: Andie MacDowell, French Stewart, Tom Dreesen
- Episode 212: Alec Baldwin, Dwight Yoakam
- Episode 213: Albert Brooks, Omar Epps
Late Show with David Letterman - Season 6 Episode 210 : Lara Flynn Boyle, David Brenner, Everclear
Dave announces that tonight, ""We're going to have good old-fashioned fun"": all night, Richard Egan stands on 53rd St. guessing the weight of passersby.
