Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Kevin James, Sheryl Crow
- Episode 2: Ricki Lake, Kid Rock
- Episode 3: Craig Kilborn, Louise Smith, The Umbilical Brothers
- Episode 4: Queen Latifah, John Popper
- Episode 5: John McEnroe, Sharon Lawrence, Nanci Griffith
- Episode 6: Kid Scientists, Edie Falco, Dixie Chicks
- Episode 7: John Leguizamo, Meat Loaf
- Episode 8: Jenna Elfman, Chris Kattan, Christine Aguilera
- Episode 9: Heather Locklear, Keyshawn Johnson
- Episode 10: Michael J. Fox, Heather French
- Episode 11: Robin Williams, Norm MacDonald
- Episode 12: Stupid Pet Tricks, Ashley Judd, Randy Travis
- Episode 13: Mark Wahlberg, Adam Sandler, Roger Ebert
- Episode 14: Kelly Preston, Stirling Moss, Sugar Ray
- Episode 15: Kevin Pollak, Tom Waits
- Episode 16: Nathan Lane, Emmylou Harris & Linda Rondstadt
- Episode 17: Mia Farrow, Russell Crowe, Paula Cole Band
- Episode 18: Kevin Spacey, Eurythmics
- Episode 19: Kelsey Grammer, Rebecca Gayheart
- Episode 20: Harrison Ford, David Bowie
- Episode 21: Dan Quayle, Melissa Ethridge
- Episode 22: Lili Tomlin, Leah Remini, Beth Hart
- Episode 23: Jesse Ventura, Amy Brennamen, ZZ Top
- Episode 24: Jack Hanna, Peter Fonda, Sting
- Episode 25: Bruce Willis, Will Ferrell
- Episode 26: Chazz Palminteri, Billy Blanks, Wilson Pickett
- Episode 27: Farrah Fawcett
- Episode 28: John Malkovich, Harland Williams
- Episode 29: Austin Payne, Patricia Arquette, Moby
- Episode 30: Charles Grodin, Jimmie Walker, Buena Vista Social Club
- Episode 31: John Cusack, Bob Sarlatte, LeAnn Rimes
- Episode 32: Martha Stewart, Martin Scorcese, Ricky Martin
- Episode 33: Joe Torre, Denzel Washington
- Episode 34: Meryl Streep, Natalie Merchant
- Episode 35: Luke Perry, Jimmy Kimmel, Garbage
- Episode 36: Lauren Holly, Jimmy Fallon, Rage Against the Machine
- Episode 37: Bill Cosby, Milla Jovovich
- Episode 38: Susan Sarandon, Juan Montoya, East Harlem Violinists
- Episode 39: Regis Philbin, Mitch Hedberg
- Episode 40: Woody Harrelson, Bobby Rahal
- Episode 41: Don Rickles, Jane Clayson
- Episode 42: Jack Hanna, Bob Hoskins, Melanie C
- Episode 43: Natalie Portman, Travis Pastrana, Ted Alexandro
- Episode 44: Stupid Human Tricks, Johnny Depp
- Episode 45: Claudia Schiffer, Chris Cornell
- Episode 46: Will Smith, Creed
- Episode 47: Anthony Edwards, Yasmine Bleeth
- Episode 48: Evander Holyfield, Ted Danson, Counting Crows
- Episode 49: Gabriel Byrne, Mark Borchardt
- Episode 50: Bryant Gumbel, John Carpenter, Tony Bennett
- Episode 51: Kathie Lee Gifford, Charlotte Church
- Episode 52: Julianna Margulies, Eric Ripert, Third Eye Blind
- Episode 53: George Carlin, Jewel
- Episode 54: Stupid Pet Tricks, William Baldwin
- Episode 55: Barbara Walter, Dan Patrick, Mary J. Blige
- Episode 56: Jenny McCarthy, Martha Stewart, Foo Fighters
- Episode 57: Tim Robbins, Laetitia Casta, B.B. King & Dr. John
- Episode 58: Patrick Stewart, Al Franken, Bob Marley
- Episode 59: Geena Davis, Bill Murray, Fiona Apple
- Episode 60: Courtney Love, Tori Murden, R.E.M.
- Episode 61: Gwyneth Paltrow, Blondie
- Episode 62: Danny DeVito, Harry Smith
- Episode 63: Jim Carrey, Alanis Morrisette
- Episode 64: Joe Breen, Jude Law
- Episode 65: Tom Brokaw, Alex Kingston, Run DMC
- Episode 66: Emily Watson, LL Cool J
- Episode 67: Marv Albert, Heather Matarazzo, Bruce Henderson
- Episode 68: Hallie Eisenberg, Jon Witherspoon, Darlene Love
- Episode 69: Matt Damon, Q-Tip
- Episode 70: Isabella Rossellini, Bev Tanner
- Episode 71: Jay Thomas, Nick Nordberg
- Episode 72: Dick Clark, Ralph Charles
- Episode 73: Stupid Human Tricks, Kevin James, Brooklyn Philharmonic
- Episode 74: Jeff Daniels, Jake Johannsen
- Episode 75: Lauren Bacall, Kurt Warner
- Episode 76: Bill Pullman, Dan Naturman
- Episode 77: George Stephanopoulos, Sue Murphy
- Episode 78: Edie Falco, Ray Lucas, Andy Kindler
- Episode 79: Kate Winslet, Ice Cube
- Episode 80: Woody Harrelson, Shawn Presser, Filter
- Episode 81: Hillary Clinton, Art Donovan
- Episode 82: Tom Arnold, Art Donovan, Lynryd Skynryd
- Episode 83: Regis Philbin, Mark Borchardt
- Episode 84: Charles Grodin, Julia Roberts, Regis Philbin
- Episode 85: Regis Philbin, Jerry Seinfeld, Danny DeVito
- Episode 86: Paul Schaffer, Bruce Willis, Martin Short
- Episode 87: Regis Philbin, Bill Cosby, Sarah Jessica Parker
- Episode 88: Paul Schaffer, Steve Martin, Billy Crystal
- Episode 89: Paul Schaffer, Drew Barrymore, Ray Romano
- Episode 90: David Brenner, Kathie Lee Gifford, Alec Baldwin
- Episode 91: Tom Snyder, Norm MacDonald, Don Rickles
- Episode 92: Tom Snyder, Mike Myers, Roseanne, Bonnie Hunt
- Episode 93: Tom Arnold, Robin Williams, Jack Hannah
- Episode 94: Regis Philbin, Robin Williams, Foo Fighters
- Episode 95: Bill Cosby, Heidi Klum, Vince Carter, Dr. Paula Mahone, Dane Cook
- Episode 96: Julia Roberts, Israel Perlman
- Episode 97: Kathie Lee Gifford, Tom Arnold, Joy Behar, Linda Edar
- Episode 98: John Goodman, Norm MacDonald
- Episode 99: Drew Carey, Dolly Parton
- Episode 100: David Brenner, Carson Daley, Aida Turturro, Gary Gulman, Ben Harper & The Innocent Criminals
- Episode 101: Kid Turkey Callers, Candice Bergan, Fiona Apple, George W. Bush
- Episode 102: Nathan Lane, Mel Brooks, Mario Cantone, Kristin Chenoweth
- Episode 103: Anjelica Huston, Jayson Williams, Steely Dan
- Episode 104: Kathie Lee Gifford, Eddie Izzard
- Episode 105: Janeane Garofalo, Bob Odenkirk & David Cross, Zack Galifanakis, Old '97s
- Episode 106: Tim Robbins, Melissa Etheridge
- Episode 107: Dana Carvey, Jon Lovitz, Cindy Margolis, Al Frankin, Rocco DiSpirito
- Episode 108: Tom Brokaw, Catherine Keener, Bonnie Raitt
- Episode 109: Gabriel Byrne, Martha Stewart, Moby
- Episode 110: Matthew Broderick, Patti Smith
- Episode 111: Barbara Walters, Linda Cardellini, Kimmie Rhodes
- Episode 112: Rosie Perez, Robert Klein
- Episode 113: Minnie Driver, Trisha Yearwood
- Episode 114: Kid Scientists, Jimmy Smits, Bruce Cockburn
- Episode 115: John Cusack, Paul Fiora, Eddie Brill
- Episode 116: David Arquette, Al Green
- Episode 117: Brooke Shields, Oliver Platt, Joni Mitchell
- Episode 118: David Duchovny, Joe Pistone, Lou Reed
- Episode 119: Bonnie Hunt, Shelby Lynne
- Episode 120: Samuel L. Jackson, Jack Hannah
- Episode 121: Jon Stewart, Faith Hill
- Episode 122: Bill Cosby, Sarah Vowell
- Episode 123: Jenna Elfman, Jeff Altman, Children of Uganda
- Episode 124: Paul Newman, Pearl Jam
- Episode 125: Matthew McConaughey, Kelly Monteith, Willie Nelson
- Episode 126: Ben Stiller, Brian Regan
- Episode 127: Jeff Foxworthy, Vertical Horizon
- Episode 128: Kristin Johnson, Live
- Episode 129: Dennis Quaid, Nicole Sullivan, Smashing Pumpkins
- Episode 130: Salma Hayek, Ray Romano
- Episode 131: Natalie Portman, Lennox Lewis
- Episode 132: David Spade, Marion Jones
- Episode 133: Kim Basinger, Oasis
- Episode 134: Dana Carvey, Alison Krauss & Union Station
- Episode 135: Julia Louis-Dreyfus, Mitch Hedberg
- Episode 136: Stupid Human Tricks, Joaquin Phoenix, Mighty Mighty Bosstones
- Episode 137: Betty White, Hanson
- Episode 138: John Travolta, Cast of Kiss me Kate
- Episode 139: Kelsey Grammer, Caroline Rhea
- Episode 140: Kathie Lee Gifford, Debra Messing
- Episode 141: Richard Simmons, Sarah Vowell
- Episode 142: Gillian Anderson, Foo Fighters
- Episode 143: David Hyde Pierce, Phish
- Episode 144: Hugh Grant, Carly Simon
- Episode 145: Jackie Chan, Jim Gaffigan
- Episode 146: Ringo Starr, Jane Krakowski
- Episode 147: Michael J. Fox, Richard Harris
- Episode 148: Earvin 'Magic' Johnson, matchbox 20
- Episode 149: Nathan Lane, Gloria Estefan
- Episode 150: Sarah Jessica Parker, Penn & Teller
- Episode 151: Dan Patrick, Owen Wilson, B.B. King
- Episode 152: Alicia Silverstone, David Brenner
- Episode 153: Lisa Kudrow, Tom Dreesen, Steve Earle and the Dukes
- Episode 154: Robert Duvall, Don Henley
- Episode 155: Roger Ebert, Nia Long
- Episode 156: Martin Lawrence, Sinead O'Connor
- Episode 157: Jimmy Connors, David Coulthard
- Episode 158: Marv Albert, Heath Ledger, Bon Jovi
- Episode 159: Calista Flockhart, Isaac Hayes
- Episode 160: Naomi Campbell, Juan Montoya
- Episode 161: Stupid Pet Tricks, Jimmy Kimmel, Billy Bragg & Wilco
- Episode 162: John McEnroe, Busta Rhymes
- Episode 163: Mark Wahlberg, The Deftones
- Episode 164: Dana Carvey, No Doubt
- Episode 165: Samuel L. Jackson, P.J. Ollson
- Episode 166: Piedmont Bird Callers, Keenan Ivory Wayans
- Episode 167: Tom Brokaw, Eric Idle
- Episode 168: James Belushi, Third Eye Blind
- Episode 169: Martha Stewart, Travis
- Episode 170: George Clooney, Warren Zevon
- Episode 171: Jay Thomas, David Sedaris
- Episode 172: Tom Arnold, Brian Wilson
- Episode 173: National Hollerin' Champions, Skye McCole Bartusiak
- Episode 174: Ellen Degeneres, Sheryl Crow & Steve Earle
- Episode 175: Daljit Dhaliwal, Shawn Wayans
- Episode 176: Jason Alexander, Tracy Chapman
- Episode 177: Bruce Willis, Elliot Smith
- Episode 178: Marilu Henner, Dixie Chicks
- Episode 179: Will Ferrell, Ben Folds Five
- Episode 180: Jeff Daniels, Bob Sarlatte
- Episode 181: Jon Stewart, Lucy Pearl
- Episode 182: Harrison Ford
- Episode 183: Don Rickles, Ween
- Episode 184: Kathie Lee Gifford, Bev Tanner
- Episode 185: Connie Chung, Harry Hill
- Episode 186: Roseanne, David Gray
- Episode 187: Edie Falco, Macy Gray
- Episode 188: Nathan Lane, John Pizzarelli Trio
- Episode 189: Joy Philbin, Joe Lockhart
- Episode 190: Al Roker, Craig Ferguson
- Episode 191: Darrell Hammond, Todd Rundgren
- Episode 192: Tom Selleck, Jordan
- Episode 193: Al Franken, Guster
- Episode 194: Sam Donaldson, Kid Rock
- Episode 195: Jennifer Lopez, Reggie Jones
- Episode 196: Vince Vaughn, Eels
Late Show with David Letterman - Season 7 Episode 4 : Queen Latifah, John Popper
John Popper sits in with the band, while Alan punches Sumner Redstone during CBS Mailbag.
