Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Wesley Snipes, Dido
- Episode 2: Jon Favreau, Stone Temple Pilots
- Episode 3: Jack Hanna, Wyclef Jean, Survivor Castaways
- Episode 4: Richard Hatch, Shaquille O'Neal
- Episode 5: Charles Grodin, Donal Logue
- Episode 6: Mary Tyler Moore, Papa Roach
- Episode 7: Ricki Lake, Adam Ferrara
- Episode 8: Rudy Giuliani, Laetitia Casta
- Episode 9: D.L. Hughley, Tony Bennett & Diana Krall
- Episode 10: Tim Robbins, Andy Kindler
- Episode 11: Carson Daly, Dwight Yoakam
- Episode 12: Renee Zellweger, Bonnie Raitt
- Episode 13: Jamie Foxx, Ben Harper and the Innocent Criminals
- Episode 14: Jesse Ventura, Spinal Tap
- Episode 15: Greg Kinnear, Jake Johannsen
- Episode 16: Marat Safin, Sting
- Episode 17: Chris Rock, Emmylou Harris
- Episode 18: Sally Field, Eddie Irvine
- Episode 19: Al Gore, Crosby Stills & Nash
- Episode 20: Kate Hudson, Supergrass
- Episode 21: Sylvester Stallone, Rocco DiSpirito
- Episode 22: Gabriel Byrne, Kevin James
- Episode 23: Denzel Washington, Mark Knopfler
- Episode 24: Ray Romano, Ralph Nader
- Episode 25: Jada Pinkett Smith, LL Cool J
- Episode 26: Geena Davis, Tom Cavanagh
- Episode 27: Christine Baranski, Green Day
- Episode 28: Farrah Fawcett, Loretta Lynn
- Episode 29: Kevin Spacey, Lenny Krayzelberg
- Episode 30: Magic Johnson, Jewel
- Episode 31: Ben Stiller, Merle Haggard
- Episode 32: Regis Philbin, Jim Gaffigan
- Episode 33: Jason Alexander, Anthony Boudain, Foo Fighters
- Episode 34: Martha Stewart, Spike Lee
- Episode 35: Mark Wahlberg, Incubus
- Episode 36: James Caan, Angela Perez Baraquio
- Episode 37: Helen Hunt, Willie Nelson
- Episode 38: Joaquin Phoenix, Allison Moorer
- Episode 39: George W. Bush
- Episode 40: Lawrence Fishburne, Lenny Kravitz
- Episode 41: Will Smith, Derek Jeter
- Episode 42: Show #1500
- Episode 43: Alec Baldwin, Gil de Ferran
- Episode 44: Kathie Lee Gifford, Mark Borchardt
- Episode 45: Madonna
- Episode 46: Don Rickles, Moby & Gwen Stefani
- Episode 47: Adam Sandler, Outkast
- Episode 48: Cokie Roberts, Patricia Arquette
- Episode 49: Lucy Liu, Aaron Neville
- Episode 50: Kid Scientists, Samuel L. Jackson
- Episode 51: Bruce Willis, Charles Barkley
- Episode 52: Mike Myers, Ricky Martin
- Episode 53: Gwyneth Paltrow, Chris Elliot
- Episode 54: Val Kilmer, Everclear
- Episode 55: Susan Sarandon, Kasey Chambers
- Episode 56: Brian Williams, Faith Hill
- Episode 57: Richard Simmons, Giselle Bundchen
- Episode 58: Stupid Human Tricks, Keri Russell
- Episode 59: Matthew Broderick, David Gray
- Episode 60: Bette Midler, Jack Hanna
- Episode 61: Martha Stewart, Christina Aquilera
- Episode 62: Jon Stewart, Everlast
- Episode 63: Mel Gibson, Todd Barry
- Episode 64: Charles Grodin, Bobby LaBonte
- Episode 65: Jay Thomas, Orny Adams
- Episode 66: Helen Hunt, Robert Klein
- Episode 67: CBS Mailbag, At the Drive-In
- Episode 68: Sean Connery, Barenaked Ladies
- Episode 69: Tom Hanks, Darlene Love
- Episode 70: George Clooney, Sade
- Episode 71: Juliette Binoche, Jonathan Witherspoon
- Episode 72: Uma Thurman, Brian Regan
- Episode 73: Lily Tomlin, Anthony Clark
- Episode 74: Jay Mohr, Snoop Dogg
- Episode 75: Benjamin Bratt, Jimmie Walker
- Episode 76: Matt Damon, Fuel
- Episode 77: Sarah Jessica Parker, Jamie Bell
- Episode 78: Tim Robbins, Julie Bowen
- Episode 79: Dennis Quaid, Jason Seahorn
- Episode 80: Kim Cattrall, Bob Sarlatte
- Episode 81: Christine Baranski, Seal
- Episode 82: Dan Rather, Vinnie Jones
- Episode 83: Sean Penn, Lauren Kessler
- Episode 84: Matthew McConaughey, Elle Macpherson
- Episode 85: Neve Campbell, George Miller
- Episode 86: Tom Selleck, Richard Ashcroft
- Episode 87: John Goodman, 3 Doors Down
- Episode 88: Dolly Parton, William Peterson
- Episode 89: Patricia Heaton, Jeff Pobst
- Episode 90: Keanu Reeves, Tony Siragusa
- Episode 91: Jack Black, Aimee Mann
- Episode 92: Anthony Hopkins, Erykah Badu
- Episode 93: Jennifer Lopez, matchbox twenty
- Episode 94: Marv Albert, Katie Holmes
- Episode 95: Regis Philbin, Rod Stewart
- Episode 96: David Boreanaz, Mitch Hedberg
- Episode 97: Kelly Ripa, Jamie Oliver
- Episode 98: Stupid Pet Tricks, Tom Cavanagh
- Episode 99: Chris Rock, Spacehog
- Episode 100: Stephanie Seymour, Nelly
- Episode 101: Megan Mullally, Eddie Brill
- Episode 102: Julia Roberts
- Episode 103: Samuel L. Jackson, Timothy Treadwell
- Episode 104: James Caan, Nelly Furtado
- Episode 105: Benicio Del Toro, Shaggy
- Episode 106: Bill O'Reilly, Jim Gaffigan
- Episode 107: Kevin Pollack, Dave Matthews Band
- Episode 108: Heather Locklear, Allison Krauss, Gillian Welch, Emmylou Harris, The Soggy Bottom Boys
- Episode 109: Tom Brokaw, Leslie Bibb
- Episode 110: Martin Short, Jake Johannsen
- Episode 111: Michael Imperiloli, Josh Joplin Group
- Episode 112: Janet Jackson, Jill Scott
- Episode 113: Denis Leary, Anne Bancroft & Liv Arnesen
- Episode 114: Cokie Roberts, Uncle Kracker
- Episode 115: Antonio Banderas, Nick Cave
- Episode 116: Kristin Davis, Grant Paulsen
- Episode 117: Jerry Seinfeld, Paul Simon
- Episode 118: George Carlin, Powderfinger
- Episode 119: Nathan Lane, Shannon Elizabeth, Cast of The Producers
- Episode 120: Jennifer Love Hewitt, Train
- Episode 121: Johnny Knoxville, The Go-Go's
- Episode 122: Isabella Rossellini, Wendy Lieberman
- Episode 123: Craig Kilborn, Warren Zevon
- Episode 124: Hugh Grant, Sade
- Episode 125: Paul Reubens, Run DMC & Stephan Jenkins
- Episode 126: David Spade, Amanda & Jonny Schwebel
- Episode 127: Carson Daley, Jann Karem, The CBS Giant Orchestra
- Episode 128: Mike Krzyzewski, Semisonic
- Episode 129: Renee Zellweger, Stephen Malkmus
- Episode 130: Holly Hunter, Idlewild
- Episode 131: Tom Green, Dr. Geoffrey Marcy
- Episode 132: LL Cool J, The Living End
- Episode 133: Liv Tyler, Billy Idol
- Episode 134: Billy Crystal, The Bee-Gees
- Episode 135: Don Rickles, Jayson Williams
- Episode 136: Sylvester Stallone, Green Day
- Episode 137: John Goodman, Jeff Stilson
- Episode 138: Kirsten Dunst, Cirque de Soleil
- Episode 139: Matthew Broderick, Brandi Chastain
- Episode 140: Regis Philbin, David Gray
- Episode 141: Bill Murray, Stevie Nicks
- Episode 142: Joan Cusack, Andy Kindler
- Episode 143: Tina Wesson, Kate Hudson, The Blind Boys of Alabama
- Episode 144: Uma Thurman, Blues Traveler
- Episode 145: Kid Scientists, Juliette Lewis
- Episode 146: Jenna Elfman, Destiny's Child
- Episode 147: Heath Ledger, Lewis Black
- Episode 148: Charlie Sheen, Missy Elliot
- Episode 149: John Travolta, R.E.M.
- Episode 150: Mike Myers, David Byrne
- Episode 151: Andrea Noceti, Jack Hannah, Ricky Martin
- Episode 152: Kelsey Grammar, Smothers Brothers
- Episode 153: Ray Romano, Dennis Tito
- Episode 154: Stupid Human Tricks, Ellen DeGeneres
- Episode 155: Alec Baldwin, Yogi Berra
- Episode 156: Tom Brokaw, Badly Drawn Boy
- Episode 157: Danny DeVito, Larry Miller
- Episode 158: Helio Castroneves, Tom Dreesen, Lucinda Williams
- Episode 159: David Duchovny, Trisha Yearwood
- Episode 160: Jimmy Fallon, The Black Crowes
- Episode 161: Dan Rather, Elvis Costello & Anne Sofie von Otter
- Episode 162: Andy Dick, Brian Regan
- Episode 163: Marv Albert, Sugar Ray
- Episode 164: Luke Perry, Jim White
- Episode 165: Kim Cattrell, Mary Chapin Carpenter
- Episode 166: Star Jones, blink-182
- Episode 167: Jon Stewart, David Brenner
- Episode 168: Dikenbe Mutombo, David Bowley, Cesaria Evora
- Episode 169: Tom Arnold, David Sedaris
- Episode 170: Jimmy Kimmel, PJ Harvey
- Episode 171: Ewan McGregor, Moby
- Episode 172: Chris Elliot, Harry Hill
- Episode 173: John McCain, Shawn Wayans
- Episode 174: Catherine Zeta-Jones, Depeche Mode
- Episode 175: Marlon Wayans, Alan Webb, Coldplay
- Episode 176: Sean Hayes, Brian Wilson, Darrius Rucker, Matthew Sweet
- Episode 177: Tony Danza, Nick DiPaolo
- Episode 178: Reese Witherspoon, Jonatha Brooke
- Episode 179: Julia Roberts, Travis
- Episode 180: Edward Norton, Dido
- Episode 181: Juliana Marguiles, George Miller
- Episode 182: Vince Vaughn, Elayne Boosler
- Episode 183: Piedmont Bird Callers, Hank Azaria, Maria McKee
- Episode 184: Kelly Ripa, Bob Sarlotte
- Episode 185: John McEnroe, Youssou N'Dour
- Episode 186: Jon Favreau, The Holmes Brothers
- Episode 187: Billy Crystal, Al Lubel
- Episode 188: Jeff Meyer, Christopher Walken, Widespread Panic
- Episode 189: Tom Selleck, David Rakoff
- Episode 190: Mark Wahlberg, Michael Lomonaco, Tegan & Sara
- Episode 191: Greg Kinnear, Afro Celt Sound System & Peter Gabriel
- Episode 192: Marilu Henner, Hugh Fink
- Episode 193: Kristin Davis, Nanci Griffith, Mark Borschardt
- Episode 194: Sean Combs
- Episode 195: Lance Armstrong, Thora Birch, Jamie O'Neal
- Episode 196: Nicole Kidman, Iggy Pop
- Episode 197: Antonio Banderas, Jeffrey Ross
Late Show with David Letterman - Season 8 Episode 128 : Mike Krzyzewski, Semisonic
Dave fumes over the reworked DVD edition of Lawrence of Arabia, and Jerry Foley letterboxes Dave and turns him blue to show the home viewers what Daddy saw on the disc. Later, he chats with Coach Mike Krzyzewski of NCAA men's hoops champ Duke University.
