Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Episode
- Episode 1: Will Ferrell, Tom Dreesen
- Episode 2: Bob Newhart, Maxwell
- Episode 3: National Hollerin' Champions, Julia Stiles, Habib Koite & Bamada
- Episode 4: Brooke Shields, John McEnroe, Joe Henry
- Episode 5: Eric Kraff, Goran Ivanisevic
- Episode 6: Connie Chung
- Episode 7: Jason Biggs, Daniel Tosh, Etta James
- Episode 8: Charles Grodin, Michael Franti & Spearhead
- Episode 9: Sarah Jessica Parker, John Witherspoon
- Episode 10: Helen Fielding, Al Lubel
- Episode 11: Tom Arnold, Brandi Chastain, Ralph Stanley & The Whites
- Episode 12: David Schwimmer, Bjork
- Episode 13: Carson Daly, US Marine Corps
- Episode 14: Tim Robbins, Amy Sedaris, Jimmy Eat World
- Episode 15: Eugene Levy, Rich Hall
- Episode 16: Dan Rather, Regis Philbin
- Episode 17: Bryant Gumbel, Denis Leary, Tori Amos
- Episode 18: Matthew Broderick, John Miller, Odetta & The Boys Choir of Harlem
- Episode 19: Walter Cronkite, Will Ferrell, Jewel
- Episode 20: Merideth Viera, Stephen Ambrose, Sheryl Crow, Emmylou Harris, and Gillian Welch
- Episode 21: Rudolph Giuliani, Katie Harmon
- Episode 22: Marcia Gay Harden, Doris Kearns Goodwin, Pete Yorn
- Episode 23: Thomas Von Essen, Ben Stiller, Tenacious D
- Episode 24: Hillary Clinton, Cast of '42nd Street'
- Episode 25: Jason Alexander, Don Zimmer, Wyclef Jean
- Episode 26: Elton John, Steve Zahn
- Episode 27: Kate Beckinsale, Chris Kattan, Sarah Harmer
- Episode 28: John Cusack, Grant Paulsen, Joe Strummer
- Episode 29: Owen Wilson, Lisa Ling, Ryan Adams
- Episode 30: Joshua Jackson, Tiki Barber, Emo Phillips
- Episode 31: Farrah Fawcett, Tina Fey, Garbage
- Episode 32: Tom Cavanagh, Steve Hartman, Leona Naess
- Episode 33: Nathan Lane, Cokie Roberts
- Episode 34: Bruce Willis, Cody Arens, Alicia Keys
- Episode 35: Rose McGowen, Sarah Vowell, Jim Gaffigan
- Episode 36: Steve Kroft, Bruce McCall, John Mellencamp
- Episode 37: Jack Hannah, Justin Long, Daniel Rodriguez
- Episode 38: Ethan Hawke, Judith Miller, Quincy Jones
- Episode 39: John McCain, Brittany Murphy, Macy Gray
- Episode 40: Kevin Kline, Richard Holbrooke, Caroline Rhea
- Episode 41: David Hyde Pierce, U2
- Episode 42: David Spade, Marv Albert, Laurie Anderson
- Episode 43: Kevin Spacey, Amy Sedaris
- Episode 44: Tom Brokaw, Gene Catron
- Episode 45: John Travolta, Harland Williams
- Episode 46: Jack Black, Tony Bennett
- Episode 47: Billy Crystal, Brittany Spears
- Episode 48: Marge Helgenberger, Gil de Ferran, Lyle Lovett
- Episode 49: Stupid Pet Tricks, Vince Vaughn, Faith Evans
- Episode 50: Richard Dreyfus, Brett Butler
- Episode 51: Martin Lawrence, Natalie Merchant
- Episode 52: Barbara Walters, David Radcliffe, Natalie Merchant
- Episode 53: Harry Connick Jr., Bernie Mac
- Episode 54: Steve Martin, Earl Scruggs
- Episode 55: Richard Harris, George Carlin
- Episode 56: Kevin James, Deion Sanders
- Episode 57: Julia Roberts, Shelby Lynne
- Episode 58: Jenna Elfman, Kid Rock
- Episode 59: David Sedaris, Five for Fighting
- Episode 60: Ray Romano, Mitch Hedberg
- Episode 61: Kelly Ripa, Mort Sahl
- Episode 62: George Clooney, Martha Stewart
- Episode 63: Noah Wyle, George Miller, Carole King
- Episode 64: Julia Stiles, Jeff Gordon
- Episode 65: Jada Pinkett Smith, Thomas Friedman
- Episode 66: Ellen DeGeneres, Dave Gorman, Kelly Goldsmith
- Episode 67: Mariah Carey, Elijah Wood, Stereophonics
- Episode 68: Andy Garcia, Chris Matthews
- Episode 69: Kid Scientists, Liv Tyler, Cake
- Episode 70: Michelle Pfeiffer, Dennis Regan
- Episode 71: Meg Ryan, Diana Krall
- Episode 72: Kevin Spacey, Jerome Bettis, Jane Monheit
- Episode 73: Jamie Foxx, Rhys Ifans, Darlene Love
- Episode 74: Marisa Tomei, Lenny Kravitz
- Episode 75: Peter Jennings, Tom Ryan
- Episode 76: Ian McKellan, Phil Simms
- Episode 77: Rudolph Giuliani, P.O.D.
- Episode 78: Lauren Graham, Eddie Brill
- Episode 79: Gwyneth Paltrow, Starsailor
- Episode 80: Cate Blanchett, Timothy Treadwell
- Episode 81: Jennifer Connelly, Colin Soloway
- Episode 82: Jack Black, Foo Fighters
- Episode 83: Tom Cruise, Tom Papa
- Episode 84: Ethan Zohn, Josh Hartnett, Remy Zero
- Episode 85: Cuba Gooding Jr., Jewel
- Episode 86: David Brenner, Howie Long, Jewel
- Episode 87: Cynthia Nixon, Mario Andretti, Willie Nelson & Rob Thomas
- Episode 88: Darrell Hammond, Elayne Boosler, Willie Nelson & Lyle Lovett
- Episode 89: Jimmy Kimmell, Julie Bowen, Cracker
- Episode 90: Bruce Willis, Ivan Neville
- Episode 91: Tim Russert, Jason Schwartzman
- Episode 92: Merv Griffin, Phantom Planet
- Episode 93: Regis Philbin, Steven Wright
- Episode 94: LL Cool J, John McEnroe
- Episode 95: Amy Brenneman, Martin Rees, Shakira
- Episode 96: Adam Vinatieri, Chris Matthews
- Episode 97: Mariska Harkitay, George Divoky, Alan Jackson
- Episode 98: Andy Richter, Jake Johannsen
- Episode 99: Janet Jackson, Enrique Iglesias
- Episode 100: Denis Leary, India.Arie
- Episode 101: Kelly Clark, Jeri Ryan
- Episode 102: Calista Flockhart, Incubus
- Episode 103: Colin Farrell, Colin Quinn
- Episode 104: Ross Powers, Mila Kunis
- Episode 105: Casey FitzRandolph, Ashleigh Banfield
- Episode 106: Simon Ammann, Kevin Bacon
- Episode 107: Halle Berry, Jonny Moseley
- Episode 108: Richard Dreyfuss, Jeff Foxworthy
- Episode 109: Jill Bakken and Vonnetta Flowers, Kelsey Grammer, Alanis Morissette
- Episode 110: Martin Short, Jack Hanna
- Episode 111: Stupid Human Tricks, Cher
- Episode 112: Tom Arnold, Nappy Roots
- Episode 113: Cokie Roberts, Al Lubel
- Episode 114: Ray Romano, Jason Kidd
- Episode 115: Regis Philbin, Andie MacDowell, Evelyn Glennie
- Episode 116: Rene Russo, Bob Sarlatte, The Chieftains
- Episode 117: John McCain, The White Stripes
- Episode 118: Jon Stewart, Kit Armstrong
- Episode 119: Bonnie Hunt, N.E.R.D.
- Episode 120: Adam Arkin, Amy Sedaris, Midnight Oil
- Episode 121: Barbara Walters, Shannon McNally
- Episode 122: Peter Krause, Doris Kearns Goodwin
- Episode 123: Robin Williams, Sevendust
- Episode 124: Andy Dick, Mike Britt
- Episode 125: Marv Albert, Charlotte Ross
- Episode 126: Tim Robbins, Jimmie Walker, Cast of Oklahoma
- Episode 127: Michael J. Fox, Patti Smith
- Episode 128: Selma Blair, Dick Enberg
- Episode 129: Bob Newhart, Demetri Martin
- Episode 130: Rosie Perez, George Miller
- Episode 131: John Ashcroft
- Episode 132: Sandra Bullock, Billy Norris, Sheryl Crow
- Episode 133: Dee Dee Davis, Cameron Diaz, The Strokes
- Episode 134: Matthew Conaughey, John Witherspoon
- Episode 135: Ashton Kutcher, Oliver Atukudzi
- Episode 136: Landon Shuffett, Seth Green, Elvis Costello
- Episode 137: Tiffani Thiessen, Bill Walton, Bonnie Raitt
- Episode 138: Charlie Sheen, Paul Westerberg
- Episode 139: The Rock, Dwayne Kennedy
- Episode 140: Charlie Sheen, Paul Westerberg
- Episode 141: Incredible Dog Challenge, Debra Messing, Wilco
- Episode 142: Kirsten Dunst, Steve Nash, Angie Stone & The O'Jays
- Episode 143: Tobey Maquire, Trey Anastasio
- Episode 144: Jennifer Garner, Jim Gaffigan
- Episode 145: Mary Tyler Moore, Norah Jones
- Episode 146: Richard Gere, Reggie Miller
- Episode 147: Will Ferrell, Tom Waits
- Episode 148: Hugh Grant, Tony Hawk
- Episode 149: Gillian Andersen, Jonathan Katz
- Episode 150: Liza Minnelli
- Episode 151: Kid Scientists, Allison Janney, Al Green
- Episode 152: Alec Baldwin, Ted Nugent
- Episode 153: Stupid Human Tricks, Natalie Portman, X-ecutioners, Xzhibit, Biohazard
- Episode 154: Kathie Lee Gifford, Brian Regan
- Episode 155: Vecepia Towerey, Hilary Swank, The Firecrackers
- Episode 156: Diane Sawyer, Jesse Martin
- Episode 157: Jennifer Lopez, April Kleinschmidt, Patty Loveless
- Episode 158: Jon Favreau, David Rakoff, Anton Figg
- Episode 159: Charles Grodin, Wendy Liebman
- Episode 160: Jimmy Kimmel, Tom Dreesen, Goo Goo Dolls
- Episode 161: Celine Dion, Helio Castroneves
- Episode 162: Chris Rock, Jack Johnson
- Episode 163: Nicolas Cage, Abi Thomas, Jimmy Eat World
- Episode 164: Zach Braff, Kathleen Madigan
- Episode 165: Christian Slater, David Bowie
- Episode 166: Sarah Michelle Gellar, John McEnroe
- Episode 167: Freddie Prinze, Jr., Alicia Keys
- Episode 168: Jodie Foster, Jack Hanna
- Episode 169: Matt Damon, Marc Maron
- Episode 170: Stupid Human Tricks, Tom Cruise, The Flatlanders
- Episode 171: Ellen DeGeneres, Al Franken
- Episode 172: Piedmont Birdcallers, Lauren Ambrose, Moby
- Episode 173: Harrison Ford, ...And You Will Know Us By The Trail of Dead
- Episode 174: Connie Chung, Gary Mule Deer
- Episode 175: Will Smith, Landon Donovan, Yo Yo Ma & The Silk Road Project
- Episode 176: National Hollering Champions, Adam Sandler, Trik Turner
- Episode 177: Tom Brokaw, Bow Wow
- Episode 178: Michelle Williams, Barry Sonnenfeld
- Episode 179: Christina Ricci, Daniel Tosh, Ben Kweller
- Episode 180: Tom Hanks, Dolly Parton
- Episode 181: Stupid Pet Tricks, Jude Law, rubyhorse
- Episode 182: Robin Williams, Pat Green
- Episode 183: Paul Newman, Counting Crows
- Episode 184: Nathan Lane, Hugh Fink
- Episode 185: Serena Williams, Tom Arnold, Dave Matthews Band
- Episode 186: Catherine Keener, Mario Batali, Solomon Burke
- Episode 187: Sarah Jessica Parker, Etta James
- Episode 188: Geena Davis, Robert Plant
- Episode 189: Ted Koppel, Wendy Liebman
- Episode 190: Haley Joel Osment, Bill Scheft, Dashboard Confessional
- Episode 191: Kristen Johnson, Kinky
- Episode 192: Dana Carvey, Ben Kilham
- Episode 193: Amy Sedaris, Chazz Palminteri, Weezer
- Episode 194: Bill Cosby, Tift Merritt
- Episode 195: Julia Stiles, Mike Daisey, Wyclef Jean
- Episode 196: Joan Rivers, Zooey Deschanel
- Episode 197: Blaine Mayhugh, Joaquin Phoenix, Little Richard
- Episode 198: Mike Myers, Bruce Springsteen & The E Street Band
- Episode 199: Bruce Springsteen & The E Street Band, Mitch Hedberg
- Episode 200: Matthew Perry, The Vines
- Episode 201: Robin Williams, James Taylor
- Episode 202: Al Pacino, Roger Clemens
- Episode 203: Elizabeth Hurley, Tom Ryan
- Episode 204: Stupid Human Tricks, Jimmy Fallon, Dirty Vegas
- Episode 205: Chris Elliot, Eliza Dushku, Dixie Chicks
- Episode 206: John Travolta, Nelly
- Episode 207: Caroline Rhea, Jake Gyllenhall
- Episode 208: Martin Short, Lewis Black
Late Show with David Letterman - Season 9 Episode 183 : Paul Newman, Counting Crows
Dave plays "Know Your Current Events" with the audience. Later, Paul Newman talks about auto racing while promoting "Road to Perdition."
